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FXR1 and SHARPIN
Number of citations of the paper that reports this interaction (PubMedID
21653829
)
98
Data Source:
BioGRID
(two hybrid)
FXR1
SHARPIN
Description
FMR1 autosomal homolog 1
SHANK associated RH domain interactor
Image
GO Annotations
Cellular Component
Nucleus
Nucleolus
Cytoplasm
Cytosol
Polysome
Postsynaptic Density
Membrane
Axon
Growth Cone
Cytoplasmic Ribonucleoprotein Granule
Neuronal Cell Body
Costamere
Dendritic Spine
Dendritic Spine Neck
Perinuclear Region Of Cytoplasm
Presynapse
Glutamatergic Synapse
Dendritic Filopodium
Ubiquitin Ligase Complex
Cytosol
Postsynaptic Density
Dendrite
LUBAC Complex
Molecular Function
RNA Binding
MRNA 3'-UTR Binding
Protein Binding
RNA Strand Annealing Activity
Protein Homodimerization Activity
Translation Regulator Activity
Protein Heterodimerization Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
Ubiquitin Binding
Protein-containing Complex Binding
Metal Ion Binding
Biological Process
Regulation Of Alternative MRNA Splicing, Via Spliceosome
Positive Regulation Of Protein Phosphorylation
Apoptotic Process
Muscle Organ Development
Negative Regulation Of Translation
Cell Differentiation
Regulation Of MRNA Stability
Positive Regulation Of Translation
Regulation Of Filopodium Assembly
Skeletal Muscle Organ Development
Positive Regulation Of Gene Silencing By MiRNA
Positive Regulation Of Response To DNA Damage Stimulus
Mitochondrion Organization
Brain Development
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Apoptotic Nuclear Changes
Keratinization
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Inflammatory Response
Protein Linear Polyubiquitination
Regulation Of CD40 Signaling Pathway
Pathways
Signaling by BRAF and RAF1 fusions
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Neurexins and neuroligins
Drugs
Diseases
GWAS
Bipolar disorder and eating disorder (
26433762
)
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Eating disorder in bipolar disorder (
26433762
)
Mastocytosis (
32752121
)
Metabolite levels (
23823483
)
Schizophrenia (
25056061
19571811
29483656
30285260
)
Asthma (
31959851
32296059
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Neutrophil percentage of granulocytes (
27863252
)
Serum metabolite levels (
23093944
)
Sum eosinophil basophil counts (
27863252
)
Interacting Genes
266 interacting genes:
ABI1
ACLY
ACOT7
ACTB
ACTG1
ACTN1
ACTN2
ADAMTSL4
AHCY
ALAS1
ANKRD40
ANKS3
AP1M1
APC2
ARHGAP22
ARHGEF7
ATN1
AXIN1
AXIN2
BCKDK
BEND5
BHLHE40
BICD1
BLK
BTBD2
BTBD6
BYSL
C1orf35
C1QBP
CA10
CACTIN-AS1
CALCOCO1
CAMK2A
CAMK2B
CAMK2G
CAPN3
CAPRIN1
CBS
CBX8
CCAR2
CCBE1
CCDC187
CCDC92
CCN3
CD86
CDC123
CDC7
CDKL3
CDR2
CDYL
CEP126
CEP72
CEP89
CHRD
CIR1
COIL
CORO1A
CORO1B
CORO6
CPLANE1
CRMP1
CSNK2A1
CSNK2B
CWF19L2
CYFIP2
CYHR1
DCTD
DCTN1
DCTN2
DCTPP1
DEAF1
DHX15
DNAJA3
DNM2
ECH1
ECHS1
ECM1
EDC4
EFEMP2
EGFL7
EIF3A
ELOA
ENO1
ERCC6
ERG28
ERVFRD-1
ESCO2
EVL
FAM161A
FAM90A1
FBLN1
FBXO4
FLAD1
FLNB
FMR1
FTH1
FXR2
GBP2
GFAP
GLYR1
GOLGA2
GOLGA3
GPSM2
GRIP1
GRIP2
GRIPAP1
HIVEP1
HLA-DRB5
HMG20A
HNRNPH2
HNRNPM
HNRNPUL1
HOMER2
HOMER3
HPRT1
HSPB1
IK
IL1RAP
IMPDH2
INA
JAKMIP1
KAZN
KCNN1
KCTD1
KCTD13
KHDRBS1
KHDRBS3
KIAA1549L
KIF17
KIF9
KRT18
LAP3
LNX1
LPP
LRIF1
LRSAM1
LUC7L2
LZTS2
MAD1L1
MAGED1
MAGOH
MAGOHB
MAPK7
MAPK8IP3
MAPKBP1
MBIP
MCRS1
MFAP1
MLLT1
MOAP1
MRPL19
MSANTD3
MTUS2
MVP
MX1
MYH10
MYH9
MYO5B
N4BP3
NBPF15
NECAB2
NECAB3
NEFL
NKD2
NME1
NME1-NME2
NME3
P3H2
PAFAH1B3
PAICS
PCCB
PCED1A
PDE9A
PHC1P1
PHC2
PHLDB1
PKM
PML
PNMA1
POLR2H
PPHLN1
PPP1R12C
PRAM1
PRKCSH
PRMT1
PRPF31
PRR13
PRSS23
PSMC3
PSMC5
PSME1
PSME3
PSPC1
PYCR1
PYCR2
PYCR3
RABAC1
RALYL
RBM26
RBM45
RCBTB2
RPIA
RUSC2
SAFB2
SAMD1
SCMH1
SEPTIN2
SERINC5
SERTAD1
SF3B2
SFPQ
SH3GL2
SH3GLB2
SHANK1
SHARPIN
SLC48A1
SLIT1
SNURF
SORBS3
SOX5
SPECC1
SPRY1
SPRY2
SRPK2
SSNA1
SST
STK16
STUB1
SUFU
SYT6
TACC2
TASOR2
TBC1D22B
TCEA2
TDRD7
TLE5
TMPO
TNFAIP1
TNIP1
TRAF2
TRAP1
TRIM3
TRIOBP
TRPM1
TSN
TTLL5
TUBB
UBAP2L
UBP1
UHRF1BP1L
USP46
UXS1
VIM
VPS51
VWF
WASH6P
WRNIP1
YES1
YY1AP1
ZMAT2
ZNF212
ZNF417
ZNF423
ZNF438
ZNF71
ZNF821
24 interacting genes:
ACTR2
ACTR3
FMR1
FXR1
ITGA1
ITGA2B
ITGA5
ITGAD
ITGAL
ITGAM
ITGB2
KRTAP6-2
KRTAP7-1
PPIL3
SHANK1
SHANK2
SHANK3
TRAF1
TRIP13
TXN2
UBC
USP54
YOD1
ZBTB32
Entrez ID
8087
81858
HPRD ID
02892
15463
Ensembl ID
ENSG00000114416
ENSG00000179526
Uniprot IDs
A0A0F7KYT8
A0A0F7L1S3
P51114
Q6PJD5
Q9H0F6
PDB IDs
2CPQ
3KUF
3O8V
4EMO
5X0W
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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