FXR1 and HLA-DRB5

Number of citations of the paper that reports this interaction (PubMedID 21653829)
98

Data Source:
BioGRID (two hybrid)

		FXR1	HLA-DRB5
Description		FMR1 autosomal homolog 1	major histocompatibility complex, class II, DR beta 5
Image
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Polysome Postsynaptic Density Membrane Axon Growth Cone Cytoplasmic Ribonucleoprotein Granule Neuronal Cell Body Costamere Dendritic Spine Dendritic Spine Neck Perinuclear Region Of Cytoplasm Presynapse Glutamatergic Synapse Dendritic Filopodium	Golgi Membrane Lysosomal Membrane Plasma Membrane ER To Golgi Transport Vesicle Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding RNA Strand Annealing Activity Protein Homodimerization Activity Translation Regulator Activity Protein Heterodimerization Activity	MHC Class II Protein Complex Binding Peptide Antigen Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Phosphorylation Apoptotic Process Muscle Organ Development Negative Regulation Of Translation Cell Differentiation Regulation Of MRNA Stability Positive Regulation Of Translation Regulation Of Filopodium Assembly Skeletal Muscle Organ Development Positive Regulation Of Gene Silencing By MiRNA Positive Regulation Of Response To DNA Damage Stimulus	Adaptive Immune Response Immunoglobulin Production Involved In Immunoglobulin-mediated Immune Response Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of T Cell Activation
Pathways		Signaling by BRAF and RAF1 fusions	Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling
Drugs			1D09C3 Coccidioides immitis spherule
Diseases
GWAS		Bipolar disorder and eating disorder ( 26433762) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Eating disorder in bipolar disorder ( 26433762) Mastocytosis ( 32752121) Metabolite levels ( 23823483) Schizophrenia ( 25056061 19571811 29483656 30285260)	Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Antinuclear antibody levels ( 25186300) Apolipoprotein A1 levels ( 32203549) Asthma ( 30929738 27182965 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Blood protein levels ( 29875488) Body mass index ( 28892062) Bullous pemphigoid ( 34011352) Childhood ear infection ( 27182965) Chronic lymphocytic leukemia ( 21131588 26956414) Crohn's disease ( 23850713) Epstein Barr virus nuclear antigen 1 IgG levels ( 26819262) Frontotemporal dementia ( 24943344) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Heart rate response to exercise ( 29769521) High density lipoprotein cholesterol levels ( 33339817) Hip circumference adjusted for BMI ( 34021172) Hypothyroidism ( 22493691) Immune response to measles vaccine (measles-induced IFN gamma) ( 28289848) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Joint damage in rheumatoid arthritis ( 31596875) Lymphocyte counts ( 32888494) Lymphoma ( 23349640) Mean spheric corpuscular volume ( 32888494) Parkinson's disease ( 21292315 27182965) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Prostate cancer ( 23535732) Refractive error ( 32231278) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Sarcoidosis (non-Lofgren's syndrome) ( 26651848) SjÃ¶gren's syndrome ( 24097066) Triglyceride levels ( 32203549) Tuberculosis ( 29036319) Type 2 diabetes ( 28869590) Ulcerative colitis ( 28067908 21297633 19122664) Vogt-Koyanagi-Harada syndrome ( 25108386) Waist-to-hip ratio adjusted for body mass index ( 26785701)
Interacting Genes		266 interacting genes: ABI1 ACLY ACOT7 ACTB ACTG1 ACTN1 ACTN2 ADAMTSL4 AHCY ALAS1 ANKRD40 ANKS3 AP1M1 APC2 ARHGAP22 ARHGEF7 ATN1 AXIN1 AXIN2 BCKDK BEND5 BHLHE40 BICD1 BLK BTBD2 BTBD6 BYSL C1orf35 C1QBP CA10 CACTIN-AS1 CALCOCO1 CAMK2A CAMK2B CAMK2G CAPN3 CAPRIN1 CBS CBX8 CCAR2 CCBE1 CCDC187 CCDC92 CCN3 CD86 CDC123 CDC7 CDKL3 CDR2 CDYL CEP126 CEP72 CEP89 CHRD CIR1 COIL CORO1A CORO1B CORO6 CPLANE1 CRMP1 CSNK2A1 CSNK2B CWF19L2 CYFIP2 CYHR1 DCTD DCTN1 DCTN2 DCTPP1 DEAF1 DHX15 DNAJA3 DNM2 ECH1 ECHS1 ECM1 EDC4 EFEMP2 EGFL7 EIF3A ELOA ENO1 ERCC6 ERG28 ERVFRD-1 ESCO2 EVL FAM161A FAM90A1 FBLN1 FBXO4 FLAD1 FLNB FMR1 FTH1 FXR2 GBP2 GFAP GLYR1 GOLGA2 GOLGA3 GPSM2 GRIP1 GRIP2 GRIPAP1 HIVEP1 HLA-DRB5 HMG20A HNRNPH2 HNRNPM HNRNPUL1 HOMER2 HOMER3 HPRT1 HSPB1 IK IL1RAP IMPDH2 INA JAKMIP1 KAZN KCNN1 KCTD1 KCTD13 KHDRBS1 KHDRBS3 KIAA1549L KIF17 KIF9 KRT18 LAP3 LNX1 LPP LRIF1 LRSAM1 LUC7L2 LZTS2 MAD1L1 MAGED1 MAGOH MAGOHB MAPK7 MAPK8IP3 MAPKBP1 MBIP MCRS1 MFAP1 MLLT1 MOAP1 MRPL19 MSANTD3 MTUS2 MVP MX1 MYH10 MYH9 MYO5B N4BP3 NBPF15 NECAB2 NECAB3 NEFL NKD2 NME1 NME1-NME2 NME3 P3H2 PAFAH1B3 PAICS PCCB PCED1A PDE9A PHC1P1 PHC2 PHLDB1 PKM PML PNMA1 POLR2H PPHLN1 PPP1R12C PRAM1 PRKCSH PRMT1 PRPF31 PRR13 PRSS23 PSMC3 PSMC5 PSME1 PSME3 PSPC1 PYCR1 PYCR2 PYCR3 RABAC1 RALYL RBM26 RBM45 RCBTB2 RPIA RUSC2 SAFB2 SAMD1 SCMH1 SEPTIN2 SERINC5 SERTAD1 SF3B2 SFPQ SH3GL2 SH3GLB2 SHANK1 SHARPIN SLC48A1 SLIT1 SNURF SORBS3 SOX5 SPECC1 SPRY1 SPRY2 SRPK2 SSNA1 SST STK16 STUB1 SUFU SYT6 TACC2 TASOR2 TBC1D22B TCEA2 TDRD7 TLE5 TMPO TNFAIP1 TNIP1 TRAF2 TRAP1 TRIM3 TRIOBP TRPM1 TSN TTLL5 TUBB UBAP2L UBP1 UHRF1BP1L USP46 UXS1 VIM VPS51 VWF WASH6P WRNIP1 YES1 YY1AP1 ZMAT2 ZNF212 ZNF417 ZNF423 ZNF438 ZNF71 ZNF821	3 interacting genes: CTAG1B FXR1 HLA-DRA
Entrez ID		8087	3127
HPRD ID		02892	09209
Ensembl ID		ENSG00000114416	ENSG00000198502
Uniprot IDs		A0A0F7KYT8 A0A0F7L1S3 P51114	A0A2Z4LKS3 Q30154
PDB IDs		2CPQ 3KUF 3O8V	1FV1 1H15 1HQR 1ZGL
Enriched GO Terms of Interacting Partners?
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