SHARPIN and ITGAD

Number of citations of the paper that reports this interaction (PubMedID 24210817)
29

Data Source:
BioGRID (unspecified method)

		SHARPIN	ITGAD
Description		SHANK associated RH domain interactor	integrin subunit alpha D
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytosol Postsynaptic Density Dendrite LUBAC Complex	Plasma Membrane Integrin Complex Cell Surface
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding	Metal Ion Binding
	Biological Process	Mitochondrion Organization Brain Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Apoptotic Nuclear Changes Keratinization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Inflammatory Response Protein Linear Polyubiquitination Regulation Of CD40 Signaling Pathway	Immune Response Integrin-mediated Signaling Pathway Heterotypic Cell-cell Adhesion
Pathways		Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Neurexins and neuroligins	Integrin cell surface interactions
Drugs
Diseases
GWAS		Asthma ( 31959851 32296059) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Serum metabolite levels ( 23093944) Sum eosinophil basophil counts ( 27863252)	Glycated hemoglobin levels ( 34059833) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 27863252) Platelet count ( 32888494) Plateletcrit ( 32888494) Red cell distribution width ( 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		24 interacting genes: ACTR2 ACTR3 FMR1 FXR1 ITGA1 ITGA2B ITGA5 ITGAD ITGAL ITGAM ITGB2 KRTAP6-2 KRTAP7-1 PPIL3 SHANK1 SHANK2 SHANK3 TRAF1 TRIP13 TXN2 UBC USP54 YOD1 ZBTB32	4 interacting genes: ICAM3 ITGB2 SHARPIN VCAM1
Entrez ID		81858	3681
HPRD ID		15463	11785
Ensembl ID		ENSG00000179526	ENSG00000156886
Uniprot IDs		Q6PJD5 Q9H0F6	Q13349 Q59H14
PDB IDs		4EMO 5X0W
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?