SHARPIN and ZBTB32

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SHARPIN	ZBTB32
Description		SHANK associated RH domain interactor	zinc finger and BTB domain containing 32
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytosol Postsynaptic Density Dendrite LUBAC Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Mitochondrion Organization Brain Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Apoptotic Nuclear Changes Keratinization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Inflammatory Response Protein Linear Polyubiquitination Regulation Of CD40 Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II
Pathways		Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Neurexins and neuroligins
Drugs
Diseases
GWAS		Asthma ( 31959851 32296059) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Serum metabolite levels ( 23093944) Sum eosinophil basophil counts ( 27863252)	Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278)
Interacting Genes		24 interacting genes: ACTR2 ACTR3 FMR1 FXR1 ITGA1 ITGA2B ITGA5 ITGAD ITGAL ITGAM ITGB2 KRTAP6-2 KRTAP7-1 PPIL3 SHANK1 SHANK2 SHANK3 TRAF1 TRIP13 TXN2 UBC USP54 YOD1 ZBTB32	55 interacting genes: ANKS1A AR ATXN1 ATXN1L BLK BOLL CAMK2A CAMK2B CCDC102B CDKN2D CFAP206 DAB1 DAZAP2 E2F6 ELF2 ERVK-6 FANCC GATA2 HNRNPF HOXD4 KRTAP15-1 KRTAP19-5 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 MIEN1 MLX MORC3 MVP MYO15B OXER1 PATZ1 PITX1 PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB1 RBPMS RBPMS2 RHOXF2 SHARPIN SPAG8 TEX37 TFAP2D TLX3 TNPO2 TXNIP VENTX WWOX ZBTB16 ZNF490
Entrez ID		81858	27033
HPRD ID		15463	12055
Ensembl ID		ENSG00000179526	ENSG00000011590
Uniprot IDs		Q6PJD5 Q9H0F6	Q9Y2Y4
PDB IDs		4EMO 5X0W	3M5B
Enriched GO Terms of Interacting Partners?
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