BRCC3 and FANCG

Number of citations of the paper that reports this interaction (PubMedID 25132264)
6

Data Source:
BioGRID (enzymatic study)

		BRCC3	FANCG
Description		BRCA1/BRCA2-containing complex subunit 3	FA complementation group G
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nuclear Ubiquitin Ligase Complex Spindle Pole Nucleus Nucleoplasm Cytoplasm Cytosol BRCA1-A Complex BRISC Complex	Nucleoplasm Nucleolus Mitochondrion Cytosol Plasma Membrane Fanconi Anaemia Nuclear Complex
	Molecular Function	Thiol-dependent Deubiquitinase Protein Binding Metallopeptidase Activity Enzyme Regulator Activity Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding Lys63-specific Deubiquitinase Activity Isopeptidase Activity	Damaged DNA Binding Protein Binding
	Biological Process	Double-strand Break Repair Mitotic G2 DNA Damage Checkpoint Signaling Response To X-ray Response To Ionizing Radiation Protein Deubiquitination Positive Regulation Of DNA Repair Regulation Of Catalytic Activity Cell Division Protein K63-linked Deubiquitination Histone H2A K63-linked Deubiquitination	Ovarian Follicle Development DNA Repair Cellular Response To DNA Damage Stimulus Mitochondrion Organization Spermatid Development Response To Radiation Interstrand Cross-link Repair
Pathways		Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Fanconi Anemia Pathway
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Venous thromboembolism ( 31676865)	Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet count ( 32888494)
Interacting Genes		12 interacting genes: ANKRD11 BRCA1 FANCG ICOS IFNAR1 NUMA1 SHMT2 SNAPC5 SUMO2 UBC UBE2D1 UIMC1	44 interacting genes: BRCA2 BRCC3 CAPN1 CBY2 CDK1 COG6 CTBP1 CYP19A1 CYP2E1 DOK5 ERCC4 FANCA FANCC FANCE FANCF FTSJ3 GABPB1 GATA1 GOLGA2 HES1 HGS IHO1 IKZF3 KRT13 KRT19 LNX2 MEOX2 NECAB2 NLGN3 PSMB1 RINT1 RTN2 SAMD3 SSX2IP TADA2A TCEANC TFIP11 TLE5 TPRX1 UIMC1 USHBP1 XRCC3 ZBED1 ZBTB1
Entrez ID		79184	2189
HPRD ID		06465	04262
Ensembl ID		ENSG00000185515	ENSG00000221829
Uniprot IDs		P46736	O15287 Q53XM5
PDB IDs		6H3C 6R8F
Enriched GO Terms of Interacting Partners?
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