BRCC3 and IFNAR1

Number of citations of the paper that reports this interaction (PubMedID 24075985)
37

Data Source:
BioGRID (enzymatic study)

		BRCC3	IFNAR1
Description		BRCA1/BRCA2-containing complex subunit 3	interferon alpha and beta receptor subunit 1
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nuclear Ubiquitin Ligase Complex Spindle Pole Nucleus Nucleoplasm Cytoplasm Cytosol BRCA1-A Complex BRISC Complex	Lysosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Thiol-dependent Deubiquitinase Protein Binding Metallopeptidase Activity Enzyme Regulator Activity Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding Lys63-specific Deubiquitinase Activity Isopeptidase Activity	Cytokine Receptor Activity Type I Interferon Receptor Activity Protein Binding Type I Interferon Binding
	Biological Process	Double-strand Break Repair Mitotic G2 DNA Damage Checkpoint Signaling Response To X-ray Response To Ionizing Radiation Protein Deubiquitination Positive Regulation Of DNA Repair Regulation Of Catalytic Activity Cell Division Protein K63-linked Deubiquitination Histone H2A K63-linked Deubiquitination	Receptor Signaling Pathway Via JAK-STAT Response To Virus Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interferon-alpha Type I Interferon Signaling Pathway Positive Regulation Of Cellular Respiration
Pathways		Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling Potential therapeutics for SARS
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Interferon alfa Human interferon omega-1 Human interferon beta
Diseases
GWAS		Venous thromboembolism ( 31676865)	Blood protein levels ( 30072576 29875488) Crohn's disease ( 23128233) Psoriasis ( 25903422)
Interacting Genes		12 interacting genes: ANKRD11 BRCA1 FANCG ICOS IFNAR1 NUMA1 SHMT2 SNAPC5 SUMO2 UBC UBE2D1 UIMC1	26 interacting genes: BRCC3 CRKL FBXW11 GART IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LAPTM4B LCK MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC RACK1 SOCS1 STAT2 STAT3 TYK2 USP7 ZAP70
Entrez ID		79184	3454
HPRD ID		06465	00126
Ensembl ID		ENSG00000185515	ENSG00000142166
Uniprot IDs		P46736	A0A494C0E2 P17181
PDB IDs		6H3C 6R8F	3S98 3SE3 3SE4 4PO6
Enriched GO Terms of Interacting Partners?
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