CCDC146 and CENPH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CCDC146	CENPH
Description		coiled-coil domain containing 146	centromere protein H
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centriole Cytoskeleton	Kinetochore Nucleus Nucleoplasm Chromosome Nucleolus Cytosol
	Molecular Function	Protein Binding	Protein Binding Kinetochore Binding
	Biological Process		Mitotic Spindle Organization Chromosome Segregation Kinetochore Assembly Kinetochore Organization
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Body mass index ( 28892062) Macrovascular complications in type 2 diabetes ( 33430853) Ophthalmic complications in type 2 diabetes ( 33430853) Response to amphetamines ( 22952603)
Interacting Genes		71 interacting genes: AKAP9 BLOC1S2 CBY2 CCDC136 CCDC197 CCNDBP1 CDR2 CDR2L CENPH CEP170P1 CEP44 DTNBP1 FSD2 GAS8 GMNN GOLGA2 GOLGA6L9 GPRASP2 GRAMD4 HSF2BP INSYN1 KIFC3 KRT16 KRT18 KRT19 KRT24 KRT26 KRT27 KRT31 KRT34 KRT38 KRT40 KRT86 LHX3 MAGEA11 MAGEA6 MCC MED4 MIPOL1 MRFAP1 MTUS2 N4BP3 NAP1L2 NECAB2 NINL NUP62 PDE4DIP PLEKHF2 PNMA1 PPP2R3C PROSER3 PSMC6 RINT1 RNF40 RPGRIP1 SH3BP1 SYCE1L TEPSIN TFIP11 THOC7 TNR TPM3 TRAF1 TRIM23 TRIM54 TRIML2 TSC22D4 TXLNA USHBP1 VPS28 VPS52	18 interacting genes: ABI2 C1orf216 C8orf58 CCDC146 DCTN2 ERH H2AP KIF2C LMNB1 MESD MTAP NDC80 NUF2 NUP54 RASSF4 SPAG5 ZNF493 ZSCAN12
Entrez ID		57639	64946
HPRD ID		11150	12029
Ensembl ID		ENSG00000135205	ENSG00000153044
Uniprot IDs		Q8IYE0 Q96MS1	A0A0S2Z5T0 Q9H3R5
PDB IDs
Enriched GO Terms of Interacting Partners?
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