RHBDD2 and MLX

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RHBDD2	MLX
Description		rhomboid domain containing 2	MAX dimerization protein MLX
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Hrd1p Ubiquitin Ligase ERAD-L Complex Nucleoplasm Golgi Apparatus Integral Component Of Endoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Membrane
	Molecular Function	Serine-type Endopeptidase Activity Misfolded Protein Binding Ubiquitin-specific Protease Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways			ChREBP activates metabolic gene expression ChREBP activates metabolic gene expression
Drugs
Diseases
GWAS		Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Sum eosinophil basophil counts ( 27863252)	Crohn's disease ( 21102463) Type 2 diabetes ( 30297969 29632382 30718926) Type 2 diabetes (time to event) ( 32589924) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		58 interacting genes: ABHD16A ACSF2 ADORA2A BCL2L1 BCL2L2 CCR9 CHRM4 CIAO2A CIDEB COL8A1 COMT DIABLO DRD2 DYNC1H1 ERBB2 FKBP8 FMO4 GAL3ST3 GCSH GDF5-AS1 H2BC3 H4C7 IFI27L1 IL32 LETMD1 LIG4 MAOB MFSD14C MICOS13 MIEF2 MLX MMRN2 MPC2 MRM1 MRPL35 MTERF3 MYG1 NAALAD2 NCBP2AS2 NFU1 NRM PBX3 PTAFR ROMO1 RSAD2 SCGB3A1 SDHD SLC25A2 SLC25A3 SNPH SYT16 TEX44 THBD TIMM17B TPRG1 TSR1 TUFM USP30	31 interacting genes: APP BACH2 BEND7 CASK CCT6A DDIT4L GABARAPL1 GABARAPL2 ID3 KRTAP13-3 LNX1 LNX2 MAD1L1 MEI4 MEOX1 MEOX2 MLXIP MLXIPL MNT MXD1 MXD4 PIAS2 RBM39 RHBDD2 SAP30BP TEPSIN TLE5 TNNT2 UBE2I ZBTB32 ZNF620
Entrez ID		57414	6945
HPRD ID		11492	04278
Ensembl ID		ENSG00000005486	ENSG00000108788
Uniprot IDs		Q6NTF9	Q9UH92
PDB IDs
Enriched GO Terms of Interacting Partners?
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