MLX and ID3

Number of citations of the paper that reports this interaction (PubMedID 18255255)
9

Data Source:
BioGRID (two hybrid)

		MLX	ID3
Description		MAX dimerization protein MLX	inhibitor of DNA binding 3, HLH protein
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Membrane	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	Protein Binding Protein Domain Specific Binding Protein Dimerization Activity Transcription Regulator Activity Transcription Regulator Inhibitor Activity Leptomycin B Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Metanephros Development Regulation Of DNA Replication Multicellular Organism Development Central Nervous System Development Heart Development Muscle Organ Development Response To Wounding Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Differentiation Neuron Differentiation Epithelial Cell Differentiation Notochord Development Circadian Regulation Of Gene Expression Odontogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Myoblast Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle Cellular Response To Leptomycin B
Pathways		ChREBP activates metabolic gene expression ChREBP activates metabolic gene expression	NGF-stimulated transcription
Drugs
Diseases
GWAS		Crohn's disease ( 21102463) Type 2 diabetes ( 30297969 29632382 30718926) Type 2 diabetes (time to event) ( 32589924) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		31 interacting genes: APP BACH2 BEND7 CASK CCT6A DDIT4L GABARAPL1 GABARAPL2 ID3 KRTAP13-3 LNX1 LNX2 MAD1L1 MEI4 MEOX1 MEOX2 MLXIP MLXIPL MNT MXD1 MXD4 PIAS2 RBM39 RHBDD2 SAP30BP TEPSIN TLE5 TNNT2 UBE2I ZBTB32 ZNF620	50 interacting genes: ADD1 ANKS1A ATF3 BOLA2 BOLA2B C22orf39 CBFA2T2 CDK2 CEP350 CNOT3 CREB5 CSK E2F4 ELK1 ELK4 FAM74A1 FHL2 FRS3 GATA4 GNB2 GTF2A1L GUCD1 HES1 HOXA1 ID4 IFI16 IKBKG KAT5 KRTAP26-1 LMO4 MLX MSGN1 MYF5 MYF6 MYOD1 MYOG PAX5 PRDM14 PUF60 RND1 RUNX1T1 SAP30 SDCBP SREBF1 TCF12 TCF3 TCF4 ZNF3 ZNF408 ZNF626
Entrez ID		6945	3399
HPRD ID		04278	02608
Ensembl ID		ENSG00000108788	ENSG00000117318
Uniprot IDs		Q9UH92	Q02535
PDB IDs			2LFH
Enriched GO Terms of Interacting Partners?
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