C1GALT1 and GPRC5D

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		C1GALT1	GPRC5D
Description		core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	G protein-coupled receptor class C group 5 member D
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Receptor Complex Extracellular Exosome
	Molecular Function	Protein Binding Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase Activity Metal Ion Binding	G Protein-coupled Receptor Activity Protein Binding Protein Kinase Activator Activity
	Biological Process	Angiogenesis Kidney Development O-glycan Processing, Core 1 Cell Differentiation	G Protein-coupled Receptor Signaling Pathway Activation Of Protein Kinase Activity
Pathways		Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) O-linked glycosylation of mucins
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 29875488) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 30224653) Erosive tooth wear (severe vs non-severe) ( 29898447) FEV1 ( 30804560) Lung function (FEV1/FVC) ( 28166213 30804560) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Multiple sclerosis (severity) ( 19010793) Night sleep phenotypes ( 27126917) Peak expiratory flow ( 30804560) Refractive error ( 32231278) Serum galactose-deficient IgA1 levels ( 28187132) Serum galactose-deficient IgA1 levels in IgA nephropathy ( 33593824) Smooth-surface caries ( 24556642) Systolic blood pressure ( 26969751) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		32 interacting genes: ANKS6 ARL13B C1GALT1C1 CD79A CPLX4 ELOVL4 FAM209A FAM210B GJA8 GJB1 GJB5 GPR101 GPR151 GPR42 GPRC5D GPX8 GSDME LEPROT LEUTX LHFPL5 MUC1 PIGP RETREG3 SLC14A1 SLC1A1 SLC7A14 STX1A TMEM14B TMEM237 TMEM52B TRAF6 XRN1	31 interacting genes: APOL3 BTN2A2 C14orf180 C1GALT1 CCL4 EMP1 ERC1 ERMP1 FXYD3 FXYD6-FXYD2 GYPA IFITM3 IGFBP5 LHFPL5 LRRC25 MS4A6A OSMR PMP22 PRRT2 PVR SLC30A2 SLC66A1 SYNDIG1 TMEM120B TMEM19 TMEM208 TMEM79 TRARG1 TWSG1 UNC93B1 YIPF1
Entrez ID		56913	55507
HPRD ID		16631	07604
Ensembl ID		ENSG00000106392	ENSG00000111291
Uniprot IDs		A0A024RA32 Q9NS00	Q9NZD1
PDB IDs
Enriched GO Terms of Interacting Partners?
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