MAP3K7 and MAPK14

Number of citations of the paper that reports this interaction (PubMedID 12589052)
87

Data Source:
HPRD (in vivo)

		MAP3K7	MAPK14
Description		mitogen-activated protein kinase kinase kinase 7	mitogen-activated protein kinase 14
Image
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Endosome Membrane	Spindle Pole Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Nuclear Speck Secretory Granule Lumen Glutamatergic Synapse Ficolin-1-rich Granule Lumen
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Receptor Tyrosine Kinase Binding Identical Protein Binding Scaffold Protein Binding Protein Serine Kinase Activity	Protein Serine/threonine Kinase Activity MAP Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Enzyme Binding Protein Phosphatase Binding Mitogen-activated Protein Kinase P38 Binding NFAT Protein Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of T Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Activation Of NF-kappaB-inducing Kinase Activity I-kappaB Phosphorylation JNK Cascade Positive Regulation Of Macroautophagy Positive Regulation Of Interleukin-2 Production Fc-epsilon Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Anoikis Positive Regulation Of JUN Kinase Activity Histone H3 Acetylation T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway	DNA Damage Checkpoint Signaling Cell Morphogenesis Cartilage Condensation Angiogenesis Osteoblast Differentiation Placenta Development Chondrocyte Differentiation Negative Regulation Of Inflammatory Response To Antigenic Stimulus Glucose Metabolic Process Regulation Of Transcription By RNA Polymerase II Apoptotic Process Chemotaxis Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Skeletal Muscle Tissue Development Positive Regulation Of Gene Expression Positive Regulation Of Myotube Differentiation Peptidyl-serine Phosphorylation Fatty Acid Oxidation Platelet Activation Regulation Of Ossification Osteoclast Differentiation Positive Regulation Of Cyclase Activity Lipopolysaccharide-mediated Signaling Pathway Response To Muramyl Dipeptide Positive Regulation Of Interleukin-12 Production Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Response To Muscle Stretch P38MAPK Cascade Positive Regulation Of Protein Import Into Nucleus Signal Transduction In Response To DNA Damage Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Glucose Import Vascular Endothelial Growth Factor Receptor Signaling Pathway Striated Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Bone Development 3'-UTR-mediated MRNA Stabilization Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Tumor Necrosis Factor Cellular Response To Ionizing Radiation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Brown Fat Cell Differentiation Cellular Senescence Stress-induced Premature Senescence Cellular Response To Virus Regulation Of Synaptic Membrane Adhesion Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Myoblast Fusion Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Activation of NF-kappaB in B cells NOD1/2 Signaling Pathway Downstream TCR signaling FCERI mediated NF-kB activation Ca2+ pathway TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NFkappaB signaling pathway CLEC7A (Dectin-1) signaling Ub-specific processing proteases TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	NOD1/2 Signaling Pathway p38MAPK events p38MAPK events ERK/MAPK targets Activation of PPARGC1A (PGC-1alpha) by phosphorylation Oxidative Stress Induced Senescence DSCAM interactions ADP signalling through P2Y purinoceptor 1 Platelet sensitization by LDL VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Activation of the AP-1 family of transcription factors KSRP (KHSRP) binds and destabilizes mRNA Myogenesis Myogenesis RHO GTPases Activate NADPH Oxidases Neutrophil degranulation Regulation of TP53 Activity through Phosphorylation CD163 mediating an anti-inflammatory response
Drugs			Minocycline Dasatinib 4-[5-[2-(1-phenyl-ethylamino)-pyrimidin-4-yl]-1-methyl-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine N-[(3Z)-5-Tert-butyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-ylidene]-N'-(4-chlorophenyl)urea 1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperidin-4-Yl-3,4-Dihydroquinolin-2(1h)-One Inhibitor of P38 Kinase 6((S)-3-Benzylpiperazin-1-Yl)-3-(Naphthalen-2-Yl)-4-(Pyridin-4-Yl)Pyrazine 3-(4-Fluorophenyl)-1-Hydroxy-2-(Pyridin-4-Yl)-1h-Pyrrolo[3,2-B]Pyridine 1-(5-Tert-Butyl-2-Methyl-2h-Pyrazol-3-Yl)-3-(4-Chloro-Phenyl)-Urea 3-(Benzyloxy)Pyridin-2-Amine 1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperazin-1-Yl-3,4-Dihydroquinazolin-2(1h)-One 4-[3-Methylsulfanylanilino]-6,7-Dimethoxyquinazoline Doramapimod 2-Chlorophenol 4-(Fluorophenyl)-1-Cyclopropylmethyl-5-(2-Amino-4-Pyrimidinyl)Imidazole SB220025 4-(2-HYDROXYBENZYLAMINO)-N-(3-(4-FLUOROPHENOXY)PHENYL)PIPERIDINE-1-SULFONAMIDE Triazolopyridine KC706 Talmapimod VX-702 R-1487 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea N-ethyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide N-[2-methyl-5-(methylcarbamoyl)phenyl]-2-{[(1R)-1-methylpropyl]amino}-1,3-thiazole-5-carboxamide Neflamapimod N-cyclopropyl-4-methyl-3-[1-(2-methylphenyl)phthalazin-6-yl]benzamide 4-PHENOXY-N-(PYRIDIN-2-YLMETHYL)BENZAMIDE 4-[5-(3-IODO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-1H-IMIDAZOL-4-YL]-PYRIDINE N-cyclopropyl-2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-carboxamide 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE 4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-yl}-1,3-thiazole-2-carbaldehyde N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-4-biphenylcarboxamide N-(cyclopropylmethyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamide N~3~-cyclopropyl-N~4~'-(cyclopropylmethyl)-6-methylbiphenyl-3,4'-dicarboxamide PH-797804 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine SD-0006 N-(3-TERT-BUTYL-1H-PYRAZOL-5-YL)-N'-{4-CHLORO-3-[(PYRIDIN-3-YLOXY)METHYL]PHENYL}UREA N-[4-CHLORO-3-(PYRIDIN-3-YLOXYMETHYL)-PHENYL]-3-FLUORO- 3-FLUORO-5-MORPHOLIN-4-YL-N-[3-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-5-YL]BENZAMIDE 3-fluoro-N-1H-indol-5-yl-5-morpholin-4-ylbenzamide 3-(1-NAPHTHYLMETHOXY)PYRIDIN-2-AMINE 3-(2-CHLOROPHENYL)-1-(2-{[(1S)-2-HYDROXY-1,2-DIMETHYLPROPYL]AMINO}PYRIMIDIN-4-YL)-1-(4-METHOXYPHENYL)UREA 8-(2-CHLOROPHENYLAMINO)-2-(2,6-DIFLUOROPHENYLAMINO)-9-ETHYL-9H-PURINE-1,7-DIIUM 2-(2,6-DIFLUOROPHENOXY)-N-(2-FLUOROPHENYL)-9-ISOPROPYL-9H-PURIN-8-AMINE N,4-dimethyl-3-[(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide N-cyclopropyl-3-{[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}-4-methylbenzamide N-cyclopropyl-4-methyl-3-{2-[(2-morpholin-4-ylethyl)amino]quinazolin-6-yl}benzamide 6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine 2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL][3-(PIPERIDIN-4-YLOXY)PHENYL]METHANONE [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL](3-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}PHENYL)METHANONE 4-[4-(4-Fluorophenyl)-2-[4-[(R)-methylsulfinyl]phenyl]-1H-imidazol-5-yl]pyridine 4-(4-FLUOROPHENYL)-1-CYCLOROPROPYLMETHYL-5-(4-PYRIDYL)-IMIDAZOLE 3-FLUORO-5-MORPHOLIN-4-YL-N-[1-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-6-YL]BENZAMIDE Fostamatinib
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma ( 31959851 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Bone mineral density (hip) ( 30172743) Celiac disease ( 20190752) Cortical surface area ( 32963231) Cortical volume ( 32963231) Graves' disease ( 21841780) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Severity of nausea and vomiting of pregnancy ( 29563502)	Foot ulcer in diabetes and neuropathy ( 28672053) Height ( 33713608) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		71 interacting genes: AKTIP ATIC BBS10 BCL10 CALML6 CARD11 CHUK COPS5 CYLD EIF2AK2 ELP1 EZH2 FBXL4 FOS GPR25 HGS HIPK2 IKBKB IL17RD IRAK1 MAILR MAP2K4 MAP2K6 MAP3K14 MAP3K3 MAP3K5 MAP4K1 MAP4K4 MAPK14 MAPK6 MAPK8 MAPK8IP1 MAVS MUL1 NAIP NDUFS6 NFKBIA NOD2 NRIP1 PEBP1 PELI3 PINK1 PPM1B PPM1L PPP2R1A PPP5C PRKAB1 RBX1 RELA RNF19A ROR2 SMAD3 SMAD6 SMAD7 STAT3 STRADB SUPT20H TAB1 TAB2 TGFBR1 TNFRSF11A TRAF3 TRAF3IP2 TRAF6 UBASH3A UBC USP4 VRK2 XIAP ZNF593 ZNF746	168 interacting genes: AIMP1 AKT1 ARNT ATF2 BCL2 BCL2L1 BICD1 BMI1 CCDC14 CCDC97 CCND2 CD4 CDC25A CDC25B CDC25C CDK4 CDK6 CDKN2A CDT1 CDX2 CENPC CEP164 COPS5 CREB1 CSNK2A1 CSNK2A2 CSNK2B DAB1 DDIT3 DUSP1 DUSP10 DUSP16 DUSP2 DUSP22 DUSP4 DUSP7 DUSP9 DYRK1B EEA1 EEF1A1 EEF2K EGFR EIF4EBP1 ELK1 ELK3 EPB42 EPHA2 EPS15 ESR1 ETV1 FGFR4 FKBP8 FLNA GADD45A GATA3 GDF15 GMFB GORASP2 GRB2 HDAC3 HIVEP1 HNF4A HSF4 HSPB1 HTRA2 ILKAP INTS6L IRAK1 JDP2 JUN JUNB KAT2A KAT2B KMT2C KRT18 KRT8 LATS2 LIMK1 MAFA MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K10 MAP3K7 MAPK1 MAPK3 MAPK8 MAPKAPK2 MAPKAPK3 MAPKAPK5 MAPT MARS1 MAX MBP MEF2A MEF2C MEF2D METTL3 MIDEAS MITF MKNK1 MKNK2 MOB3B MUC12 MYC NCOA3 NF2 NFATC1 NFATC4 NFIC NKTR NRL NUP153 PAK6 PHC2 PI4K2B PLA2G4A PLG PML PPARGC1A PPP4R3A PTPN7 RB1 RBSN RELA RET ROBO1 RPL22 RPL41 RPS6KA4 RPS6KA5 S100A9 SCN8A SH2D1A SHC1 SLC9A1 SMAD3 SMAD7 SMARCD3 SNAPIN SP7 SPAG9 SPTBN1 SQSTM1 SRPK1 SRSF5 STAT1 STAT4 STK11 STK39 SUPT20H TAB1 TCF20 TFCP2 TLE5 TMEM63B TNFRSF4 TP53 TRAF6 TSC1 UGT2B10 ULK1 YY1AP1 ZFP36L1 ZNF142 ZNHIT1
Entrez ID		6885	1432
HPRD ID		04011	02619
Ensembl ID		ENSG00000135341	ENSG00000112062
Uniprot IDs		O43318	A0A024RD15 B4E0K5 L7RSM2 Q16539
PDB IDs		2EVA 2YIY 4GS6 4L3P 4L52 4L53 4O91 5E7R 5GJD 5GJF 5GJG 5J7S 5J8I 5J9L 5JGA 5JGB 5JGD 5JH6 5JK3 5V5N	1A9U 1BL6 1BL7 1BMK 1DI9 1IAN 1KV1 1KV2 1M7Q 1OUK 1OUY 1OVE 1OZ1 1R39 1R3C 1W7H 1W82 1W83 1W84 1WBN 1WBO 1WBS 1WBT 1WBV 1WBW 1WFC 1YQJ 1ZYJ 1ZZ2 1ZZL 2BAJ 2BAK 2BAL 2BAQ 2FSL 2FSM 2FSO 2FST 2GFS 2I0H 2LGC 2NPQ 2OKR 2ONL 2QD9 2RG5 2RG6 2Y8O 2YIS 2YIW 2YIX 2ZAZ 2ZB0 2ZB1 3BV2 3BV3 3BX5 3C5U 3CTQ 3D7Z 3D83 3DS6 3DT1 3E92 3E93 3FC1 3FI4 3FKL 3FKN 3FKO 3FL4 3FLN 3FLQ 3FLS 3FLW 3FLY 3FLZ 3FMH 3FMJ 3FMK 3FML 3FMM 3FMN 3FSF 3FSK 3GC7 3GCP 3GCQ 3GCS 3GCU 3GCV 3GFE 3GI3 3HA8 3HEC 3HEG 3HL7 3HLL 3HP2 3HP5 3HRB 3HUB 3HUC 3HV3 3HV4 3HV5 3HV6 3HV7 3HVC 3IPH 3ITZ 3IW5 3IW6 3IW7 3IW8 3K3I 3K3J 3KF7 3KQ7 3L8S 3L8X 3LFA 3LFB 3LFC 3LFD 3LFE 3LFF 3LHJ 3MGY 3MH0 3MH1 3MH2 3MH3 3MPA 3MPT 3MVL 3MVM 3MW1 3NEW 3NNU 3NNV 3NNW 3NNX 3NWW 3O8P 3O8T 3O8U 3OBG 3OBJ 3OC1 3OCG 3OD6 3ODY 3ODZ 3OEF 3PG3 3QUD 3QUE 3RIN 3ROC 3S3I 3S4Q 3U8W 3UVP 3UVQ 3UVR 3ZS5 3ZSG 3ZSH 3ZSI 3ZYA 4A9Y 4AA0 4AA4 4AA5 4AAC 4DLI 4DLJ 4E5A 4E5B 4E6A 4E6C 4E8A 4EH2 4EH3 4EH4 4EH5 4EH6 4EH7 4EH8 4EH9 4EHV 4EWQ 4F9W 4F9Y 4FA2 4GEO 4KIN 4KIP 4KIQ 4L8M 4R3C 4ZTH 5ETA 5ETC 5ETF 5ETI 5ML5 5MTX 5MTY 5MZ3 5N63 5N64 5N65 5N66 5N67 5N68 5O8U 5O8V 5OMG 5OMH 5TBE 5TCO 5WJJ 5XYX 5XYY 6ANL 6HWT 6HWU 6HWV 6M95 6M9L 6OHD 6QDZ 6QE1 6QYX 6RFO 6SFI 6SFJ 6SFK 6SFO 6TCA 6ZQS 6ZWP
Enriched GO Terms of Interacting Partners?
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