HiPPIP
Home
About
SZ Genes
People
Help
Advanced Search
MAP3K7 and TNFRSF11A
Number of citations of the paper that reports this interaction (PubMedID
11809792
)
89
Data Source:
HPRD
(in vivo)
MAP3K7
TNFRSF11A
Description
mitogen-activated protein kinase kinase kinase 7
TNF receptor superfamily member 11a
Image
GO Annotations
Cellular Component
Nucleus
Cytosol
Plasma Membrane
Endosome Membrane
Cytosol
Plasma Membrane
External Side Of Plasma Membrane
Integral Component Of Membrane
Molecular Function
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
MAP Kinase Kinase Kinase Kinase Activity
Receptor Tyrosine Kinase Binding
Identical Protein Binding
Scaffold Protein Binding
Protein Serine Kinase Activity
Transmembrane Signaling Receptor Activity
Tumor Necrosis Factor-activated Receptor Activity
Protein Binding
Cytokine Binding
Signaling Receptor Activity
Metal Ion Binding
Biological Process
MAPK Cascade
Stimulatory C-type Lectin Receptor Signaling Pathway
Positive Regulation Of T Cell Cytokine Production
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Activation Of NF-kappaB-inducing Kinase Activity
I-kappaB Phosphorylation
JNK Cascade
Positive Regulation Of Macroautophagy
Positive Regulation Of Interleukin-2 Production
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Anoikis
Positive Regulation Of JUN Kinase Activity
Histone H3 Acetylation
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Ossification
Adaptive Immune Response
Monocyte Chemotaxis
Signal Transduction
Cell-cell Signaling
Positive Regulation Of Cell Population Proliferation
Response To Radiation
Osteoclast Differentiation
Response To Lipopolysaccharide
Tumor Necrosis Factor-mediated Signaling Pathway
Response To Cytokine
Response To Tumor Necrosis Factor
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Bone Resorption
Lymph Node Development
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Circadian Temperature Homeostasis
Mammary Gland Alveolus Development
Response To Interleukin-1
Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion
TNFSF11-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade Via TNFSF11-mediated Signaling
Multinuclear Osteoclast Differentiation
Pathways
Activation of NF-kappaB in B cells
NOD1/2 Signaling Pathway
Downstream TCR signaling
FCERI mediated NF-kB activation
Ca2+ pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TNFR1-induced NFkappaB signaling pathway
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Alpha-protein kinase 1 signaling pathway
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs
ENMD-1198
Diseases
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Asthma (
31959851
29273806
)
Asthma (adult onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Bone mineral density (hip) (
30172743
)
Celiac disease (
20190752
)
Cortical surface area (
32963231
)
Cortical volume (
32963231
)
Graves' disease (
21841780
)
Response to anti-TNF therapy in rheumatoid arthritis (
26776603
)
Response to inhaled corticosteroid treatment in asthma (change in FEV1) (
24792382
)
Severity of nausea and vomiting of pregnancy (
29563502
)
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
32296059
)
Asthma (age of onset) (
31036433
)
Asthma (childhood onset) (
31036433
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Blood protein levels (
30072576
29875488
)
Bone mineral density (paediatric, skull) (
24945404
)
Bone mineral density (spine) (
19801982
)
Femoral neck bone mineral density (
29499414
)
Heel bone mineral density (
30598549
28869591
)
Lumbar spine bone mineral density (
29499414
22504420
)
Myasthenia gravis (
25643325
)
Paget's disease (
21623375
20436471
)
Response to antipsychotic treatment (
23241943
)
Serum albumin level (
23022100
)
Serum alkaline phosphatase levels (
33547301
29403010
33339817
)
Vitiligo (
27723757
)
Interacting Genes
71 interacting genes:
AKTIP
ATIC
BBS10
BCL10
CALML6
CARD11
CHUK
COPS5
CYLD
EIF2AK2
ELP1
EZH2
FBXL4
FOS
GPR25
HGS
HIPK2
IKBKB
IL17RD
IRAK1
MAILR
MAP2K4
MAP2K6
MAP3K14
MAP3K3
MAP3K5
MAP4K1
MAP4K4
MAPK14
MAPK6
MAPK8
MAPK8IP1
MAVS
MUL1
NAIP
NDUFS6
NFKBIA
NOD2
NRIP1
PEBP1
PELI3
PINK1
PPM1B
PPM1L
PPP2R1A
PPP5C
PRKAB1
RBX1
RELA
RNF19A
ROR2
SMAD3
SMAD6
SMAD7
STAT3
STRADB
SUPT20H
TAB1
TAB2
TGFBR1
TNFRSF11A
TRAF3
TRAF3IP2
TRAF6
UBASH3A
UBC
USP4
VRK2
XIAP
ZNF593
ZNF746
14 interacting genes:
CBL
CBLB
ETFA
FHL2
GAB2
MAP3K7
SRC
TAB2
TNFSF11
TRAF1
TRAF2
TRAF3
TRAF5
TRAF6
Entrez ID
6885
8792
HPRD ID
04011
04609
Ensembl ID
ENSG00000135341
ENSG00000141655
Uniprot IDs
O43318
Q9Y6Q6
PDB IDs
2EVA
2YIY
4GS6
4L3P
4L52
4L53
4O91
5E7R
5GJD
5GJF
5GJG
5J7S
5J8I
5J9L
5JGA
5JGB
5JGD
5JH6
5JK3
5V5N
1LB5
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?