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MAP3K7 and HIPK2
Number of citations of the paper that reports this interaction (PubMedID
15082531
)
69
Data Source:
BioGRID
(enzymatic study)
HPRD
(in vitro)
MAP3K7
HIPK2
Description
mitogen-activated protein kinase kinase kinase 7
homeodomain interacting protein kinase 2
Image
GO Annotations
Cellular Component
Nucleus
Cytosol
Plasma Membrane
Endosome Membrane
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Body
PML Body
RNA Polymerase II Transcription Regulator Complex
Molecular Function
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
MAP Kinase Kinase Kinase Kinase Activity
Receptor Tyrosine Kinase Binding
Identical Protein Binding
Scaffold Protein Binding
Protein Serine Kinase Activity
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
SMAD Binding
Virion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Protein Serine Kinase Activity
Biological Process
MAPK Cascade
Stimulatory C-type Lectin Receptor Signaling Pathway
Positive Regulation Of T Cell Cytokine Production
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Activation Of NF-kappaB-inducing Kinase Activity
I-kappaB Phosphorylation
JNK Cascade
Positive Regulation Of Macroautophagy
Positive Regulation Of Interleukin-2 Production
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Anoikis
Positive Regulation Of JUN Kinase Activity
Histone H3 Acetylation
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Eye Development
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Transforming Growth Factor Beta Receptor Signaling Pathway
Smoothened Signaling Pathway
Adult Walking Behavior
Positive Regulation Of Cell Population Proliferation
Anterior/posterior Pattern Specification
Retina Layer Formation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Neuron Differentiation
Erythrocyte Differentiation
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
PML Body Organization
Positive Regulation Of Protein Binding
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of DNA Binding
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Embryonic Camera-type Eye Morphogenesis
Voluntary Musculoskeletal Movement
Positive Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Cell Cycle
Embryonic Retina Morphogenesis In Camera-type Eye
Lens Induction In Camera-type Eye
SMAD Protein Signal Transduction
Iris Morphogenesis
Cellular Response To Hypoxia
Intrinsic Apoptotic Signaling Pathway
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
Activation of NF-kappaB in B cells
NOD1/2 Signaling Pathway
Downstream TCR signaling
FCERI mediated NF-kB activation
Ca2+ pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TNFR1-induced NFkappaB signaling pathway
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Alpha-protein kinase 1 signaling pathway
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
YAP1- and WWTR1 (TAZ)-stimulated gene expression
SUMOylation of transcription cofactors
Physiological factors
Regulation of TP53 Activity through Phosphorylation
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of MECP2 expression and activity
Drugs
Fostamatinib
Diseases
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Asthma (
31959851
29273806
)
Asthma (adult onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Bone mineral density (hip) (
30172743
)
Celiac disease (
20190752
)
Cortical surface area (
32963231
)
Cortical volume (
32963231
)
Graves' disease (
21841780
)
Response to anti-TNF therapy in rheumatoid arthritis (
26776603
)
Response to inhaled corticosteroid treatment in asthma (change in FEV1) (
24792382
)
Severity of nausea and vomiting of pregnancy (
29563502
)
Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis (
26980576
)
Systolic blood pressure (
28135244
)
Interacting Genes
71 interacting genes:
AKTIP
ATIC
BBS10
BCL10
CALML6
CARD11
CHUK
COPS5
CYLD
EIF2AK2
ELP1
EZH2
FBXL4
FOS
GPR25
HGS
HIPK2
IKBKB
IL17RD
IRAK1
MAILR
MAP2K4
MAP2K6
MAP3K14
MAP3K3
MAP3K5
MAP4K1
MAP4K4
MAPK14
MAPK6
MAPK8
MAPK8IP1
MAVS
MUL1
NAIP
NDUFS6
NFKBIA
NOD2
NRIP1
PEBP1
PELI3
PINK1
PPM1B
PPM1L
PPP2R1A
PPP5C
PRKAB1
RBX1
RELA
RNF19A
ROR2
SMAD3
SMAD6
SMAD7
STAT3
STRADB
SUPT20H
TAB1
TAB2
TGFBR1
TNFRSF11A
TRAF3
TRAF3IP2
TRAF6
UBASH3A
UBC
USP4
VRK2
XIAP
ZNF593
ZNF746
54 interacting genes:
AATF
ABL1
BTRC
CBX3
CHMP4B
CREBBP
CUL1
CXCL1
DAXX
DDX39A
DDX39B
FBXW7
H2BC21
HMGA1
KAT2B
MAP3K7
MBP
MDM2
MECP2
MKNK1
MYB
MYBL1
NKX2-1
NKX2-5
NKX3-1
NLK
NTRK1
PARP1
PAX6
PML
PTCH1
RANBP9
RUNX1
SCAP
SENP1
SIAH1
SIAH2
SIRT1
SKI
SMAD1
SMAD2
SMAD3
SP100
SUMO1
SUMO2
SUMO3
TP53
TP53INP1
TP63
TP73
TRADD
UBE2I
WSB1
ZBTB4
Entrez ID
6885
28996
HPRD ID
04011
06039
Ensembl ID
ENSG00000135341
ENSG00000064393
Uniprot IDs
O43318
Q9H2X6
PDB IDs
2EVA
2YIY
4GS6
4L3P
4L52
4L53
4O91
5E7R
5GJD
5GJF
5GJG
5J7S
5J8I
5J9L
5JGA
5JGB
5JGD
5JH6
5JK3
5V5N
6P5S
7NCF
Enriched GO Terms of Interacting Partners
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