PDE4A and OSGIN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PDE4A	OSGIN1
Description		phosphodiesterase 4A	oxidative stress induced growth inhibitor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane Perinuclear Region Of Cytoplasm	Cellular_component
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding CAMP Binding Metal Ion Binding	Protein Binding Growth Factor Activity
	Biological Process	CAMP Catabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Smell Regulation Of Protein Kinase A Signaling Regulation Of CAMP-mediated Signaling Cellular Response To Xenobiotic Stimulus	Signal Transduction Cell Differentiation Negative Regulation Of Cell Growth Regulation Of Cell Migration Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process
Pathways		DARPP-32 events G alpha (s) signalling events
Drugs		Caffeine Theophylline Dyphylline Enprofylline Dipyridamole Iloprost Oxtriphylline Amrinone Roflumilast Piclamilast Crisaborole Ibudilast Propentofylline Drotaverine (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Tofisopam Trapidil
Diseases
GWAS		Blood protein levels ( 28240269) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) LDL cholesterol levels in HIV infection ( 33109212) Multiple sclerosis ( 31604244) Plateletcrit ( 32888494)	Alanine aminotransferase levels ( 33547301) LDL cholesterol ( 30275531) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Pursuit maintenance gain ( 29064472) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		7 interacting genes: AIP CYB561D2 LYN OSGIN1 PFKFB1 PIAS4 SMARCA4	47 interacting genes: AKT1 ARNT2 ATM BCAR3 BEND7 BTBD2 CAPN3 CCDC33 CENPN CRX DECR2 DNAJA3 FGFR4 GCLM HOMEZ IKBKG IKZF3 INCA1 KATNBL1 KRAS KRT75 LNX1 MEI4 MEIS2 MEOX1 MEOX2 MTERF4 PAX5 PDE4A PDE4C PICK1 POLDIP3 POLR2G PPM1D PTEN REL SAXO1 SMARCB1 SORBS3 TCF12 TCF4 TLE5 TRIM54 XRCC3 ZBTB42 ZC2HC1C ZKSCAN4
Entrez ID		5141	29948
HPRD ID		02527	06412
Ensembl ID		ENSG00000065989	ENSG00000140961
Uniprot IDs		P27815	Q9UJX0
PDB IDs		2QYK 3I8V 3TVX
Enriched GO Terms of Interacting Partners?
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