OSGIN1 and GCLM

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		OSGIN1	GCLM
Description		oxidative stress induced growth inhibitor 1	glutamate-cysteine ligase modifier subunit
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component	Cytosol Glutamate-cysteine Ligase Complex
	Molecular Function	Protein Binding Growth Factor Activity	Glutamate-cysteine Ligase Activity Protein Binding Enzyme Regulator Activity Glutamate-cysteine Ligase Catalytic Subunit Binding Protein-containing Complex Binding D-threo-aldose 1-dehydrogenase Activity
	Biological Process	Signal Transduction Cell Differentiation Negative Regulation Of Cell Growth Regulation Of Cell Migration Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process	Cysteine Metabolic Process Glutamate Metabolic Process Glutathione Biosynthetic Process Response To Oxidative Stress Aging Response To Nutrient Apoptotic Mitochondrial Changes Response To Xenobiotic Stimulus Response To Activity Positive Regulation Of Glutamate-cysteine Ligase Activity Cellular Response To Hepatocyte Growth Factor Stimulus Hepatic Stellate Cell Activation Negative Regulation Of Neuron Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Human Chorionic Gonadotropin Response To Nitrosative Stress Regulation Of Mitochondrial Depolarization Cellular Response To Glucose Stimulus Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Thyroxine Stimulus Blood Vessel Diameter Maintenance Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Glutathione synthesis and recycling Defective GCLC causes HAGGSD
Drugs			Glutamic acid Cysteine
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) LDL cholesterol ( 30275531) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Pursuit maintenance gain ( 29064472) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Serum alkaline phosphatase levels ( 33547301)	Metabolite levels ( 23823483) Ovarian cancer ( 30557369) Refractive error ( 32231278) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		47 interacting genes: AKT1 ARNT2 ATM BCAR3 BEND7 BTBD2 CAPN3 CCDC33 CENPN CRX DECR2 DNAJA3 FGFR4 GCLM HOMEZ IKBKG IKZF3 INCA1 KATNBL1 KRAS KRT75 LNX1 MEI4 MEIS2 MEOX1 MEOX2 MTERF4 PAX5 PDE4A PDE4C PICK1 POLDIP3 POLR2G PPM1D PTEN REL SAXO1 SMARCB1 SORBS3 TCF12 TCF4 TLE5 TRIM54 XRCC3 ZBTB42 ZC2HC1C ZKSCAN4	4 interacting genes: CALM1 IRF7 OSGIN1 STOX1
Entrez ID		29948	2730
HPRD ID		06412	03106
Ensembl ID		ENSG00000140961	ENSG00000023909
Uniprot IDs		Q9UJX0	P48507
PDB IDs
Enriched GO Terms of Interacting Partners?
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