OSGIN1 and CENPN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		OSGIN1	CENPN
Description		oxidative stress induced growth inhibitor 1	centromere protein N
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component	Kinetochore Nucleoplasm Cytosol
	Molecular Function	Protein Binding Growth Factor Activity
	Biological Process	Signal Transduction Cell Differentiation Negative Regulation Of Cell Growth Regulation Of Cell Migration Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process	Chromosome Segregation Kinetochore Assembly
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) LDL cholesterol ( 30275531) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Pursuit maintenance gain ( 29064472) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Serum alkaline phosphatase levels ( 33547301)	Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		47 interacting genes: AKT1 ARNT2 ATM BCAR3 BEND7 BTBD2 CAPN3 CCDC33 CENPN CRX DECR2 DNAJA3 FGFR4 GCLM HOMEZ IKBKG IKZF3 INCA1 KATNBL1 KRAS KRT75 LNX1 MEI4 MEIS2 MEOX1 MEOX2 MTERF4 PAX5 PDE4A PDE4C PICK1 POLDIP3 POLR2G PPM1D PTEN REL SAXO1 SMARCB1 SORBS3 TCF12 TCF4 TLE5 TRIM54 XRCC3 ZBTB42 ZC2HC1C ZKSCAN4	4 interacting genes: ALKBH7 CCDC103 OSGIN1 TSSK3
Entrez ID		29948	55839
HPRD ID		06412	12528
Ensembl ID		ENSG00000140961	ENSG00000166451
Uniprot IDs		Q9UJX0	Q96H22
PDB IDs			6BUZ 6C0W 6EQT 6MUO 6MUP
Enriched GO Terms of Interacting Partners?
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