PDE4A and CYB561D2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PDE4A	CYB561D2
Description		phosphodiesterase 4A	cytochrome b561 family member D2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane Vesicle
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding CAMP Binding Metal Ion Binding	Protein Binding Oxidoreductase Activity Heme Binding Metal Ion Binding Transmembrane Ascorbate Ferrireductase Activity Transmembrane Monodehydroascorbate Reductase Activity
	Biological Process	CAMP Catabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Smell Regulation Of Protein Kinase A Signaling Regulation Of CAMP-mediated Signaling Cellular Response To Xenobiotic Stimulus	Transmembrane Transport Ascorbate Homeostasis
Pathways		DARPP-32 events G alpha (s) signalling events
Drugs		Caffeine Theophylline Dyphylline Enprofylline Dipyridamole Iloprost Oxtriphylline Amrinone Roflumilast Piclamilast Crisaborole Ibudilast Propentofylline Drotaverine (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Tofisopam Trapidil
Diseases
GWAS		Blood protein levels ( 28240269) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) LDL cholesterol levels in HIV infection ( 33109212) Multiple sclerosis ( 31604244) Plateletcrit ( 32888494)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		7 interacting genes: AIP CYB561D2 LYN OSGIN1 PFKFB1 PIAS4 SMARCA4	22 interacting genes: APP ARL13B CD79A CLDN7 CLEC14A CLNK COQ9 CREB3L1 ERGIC3 FAM209A GPX8 LMNA PDE4A PGRMC2 PSCA PTPN5 RMDN3 SLC18A1 SLC30A2 TMEM154 TMEM45B UNC119
Entrez ID		5141	11068
HPRD ID		02527	06143
Ensembl ID		ENSG00000065989	ENSG00000114395
Uniprot IDs		P27815	A0A024R342 O14569
PDB IDs		2QYK 3I8V 3TVX
Enriched GO Terms of Interacting Partners?
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