NCBP1 and RPS6KB1

Number of citations of the paper that reports this interaction (PubMedID 10973943)
25

Data Source:
HPRD (in vivo)

		NCBP1	RPS6KB1
Description		nuclear cap binding protein subunit 1	ribosomal protein S6 kinase B1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Cytosol MRNA Cap Binding Complex Nuclear Cap Binding Complex RNA Cap Binding Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Neuron Projection Synapse
	Molecular Function	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding MRNA Binding Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Spliceosomal Complex Assembly 7-methylguanosine MRNA Capping RNA Catabolic Process MRNA Export From Nucleus Regulation Of Translational Initiation RNA Splicing Positive Regulation Of Cell Growth Gene Silencing By RNA Positive Regulation Of MRNA 3'-end Processing MRNA Cis Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Pre-mRNA Cleavage Required For Polyadenylation Regulation Of MRNA Polyadenylation Positive Regulation Of RNA Binding	G1/S Transition Of Mitotic Cell Cycle Apoptotic Process Signal Transduction Peptidyl-serine Phosphorylation Response To Nutrient Levels TOR Signaling Cellular Response To Insulin Stimulus Negative Regulation Of Apoptotic Process Long-chain Fatty Acid Import Into Cell Positive Regulation Of Translation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Translational Initiation Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Cellular Response To Growth Factor Stimulus
Pathways		SLBP independent Processing of Histone Pre-mRNAs Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Abortive elongation of HIV-1 transcript in the absence of Tat snRNP Assembly RNA Polymerase II Pre-transcription Events FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Processing of Intronless Pre-mRNAs Signaling by FGFR2 IIIa TM Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	mTORC1-mediated signalling
Drugs
Diseases
GWAS		Thyroid cancer (Papillary, radiation-related) ( 20350937)	Body shape index ( 34021172) C-reactive protein levels ( 30388399) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia or multiple sclerosis ( 31407831) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088) Obesity-related traits ( 23251661) Triglycerides ( 30275531)
Interacting Genes		19 interacting genes: BNIP1 BNIP2 BNIP3 EIF4G1 EIF4G2 HNRNPF HNRNPH1 LINC01554 NCBP2 NUP214 PSTPIP1 PTEN RNF20 RNF40 RPS6KB1 SELENOS SNRPA1 STAU1 ZDHHC17	62 interacting genes: ACTA1 AKT1 APP BTK CDC42 CDK1 CLEC3B COASY CSNK2A1 CSNK2B CYB5R3 DEPTOR DPPA4 EEF2K EIF3B EIF3F EIF4B EIF4EBP1 EP300 FBXO7 GDI2P1 GRIA1 HTT IRS1 KAT2B KIR3DL1 LYN MAPK1 MAPK3 MAPK8 MAPK9 MAPT MARK2 MTOR MXD1 NCBP1 NEDD4 NEK6 NR1I2 PDK1 PDPK1 PIK3CA PIN1 PIP4K2A POLDIP3 PPP1R9A PPP1R9B PPP2CA RAC1 RBX1 RHEB RPS6 RPTOR SRC STK11 SYK TBK1 TERT TRAF4 URI1 USP11 XPO1
Entrez ID		4686	6198
HPRD ID		02717	10202
Ensembl ID		ENSG00000136937	ENSG00000108443
Uniprot IDs		A0A024R179 Q09161	P23443
PDB IDs		1H2T 1H2U 1H2V 1H6K 1N52 1N54 3FEX 3FEY 5OO6 5OOB 6D0Y 7ABG	3A60 3A61 3A62 3WE4 3WF5 3WF6 3WF7 3WF8 3WF9 4L3J 4L3L 4L42 4L43 4L44 4L45 4L46 4RLO 4RLP 5WBH 5WBK
Enriched GO Terms of Interacting Partners?
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