RPS6KB1 and HTT

Number of citations of the paper that reports this interaction (PubMedID 23443539)
38

Data Source:
BioGRID (unspecified method)

		RPS6KB1	HTT
Description		ribosomal protein S6 kinase B1	huntingtin
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Neuron Projection Synapse	Nucleus Nucleoplasm Cytoplasm Early Endosome Late Endosome Autophagosome Endoplasmic Reticulum Golgi Apparatus Centriole Cytosol Inclusion Body Axon Dendrite Cytoplasmic Vesicle Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	P53 Binding Protein Binding Profilin Binding Kinase Binding Heat Shock Protein Binding Dynactin Binding Identical Protein Binding Transmembrane Transporter Binding Dynein Intermediate Chain Binding Beta-tubulin Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Apoptotic Process Signal Transduction Peptidyl-serine Phosphorylation Response To Nutrient Levels TOR Signaling Cellular Response To Insulin Stimulus Negative Regulation Of Apoptotic Process Long-chain Fatty Acid Import Into Cell Positive Regulation Of Translation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Translational Initiation Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Cellular Response To Growth Factor Stimulus	Establishment Of Mitotic Spindle Orientation Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Apoptotic Process Golgi Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Destabilization Vocal Learning Positive Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Cilium Assembly Vesicle Transport Along Microtubule Microtubule-based Transport Positive Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Lipophagy Regulation Of CAMKK-AMPK Signaling Cascade Positive Regulation Of Aggrephagy Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		mTORC1-mediated signalling	Regulation of MECP2 expression and activity
Drugs			Copper
Diseases
GWAS		Body shape index ( 34021172) C-reactive protein levels ( 30388399) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia or multiple sclerosis ( 31407831) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088) Obesity-related traits ( 23251661) Triglycerides ( 30275531)	Age at first birth ( 34211149) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alcohol consumption ( 31358974) Estimated glomerular filtration rate ( 31152163) Frailty index ( 34431594) Hip circumference adjusted for BMI ( 34021172) Household income (MTAG) ( 31844048) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean platelet volume ( 32888494) Monobrow ( 27182965) Myocardial infarction ( 33532862) Neutrophil count ( 32888494) Parental lifespan ( 30642433) Platelet count ( 32888494) Serum sulfate level ( 27412988) Tuberculosis ( 29036319) Type 2 diabetes ( 30297969) Walking pace ( 33128006) White blood cell count ( 32888494) Worry too long after an embarrassing experience ( 29500382) Worry/vulnerability (special factor of neuroticism) ( 30867560)
Interacting Genes		62 interacting genes: ACTA1 AKT1 APP BTK CDC42 CDK1 CLEC3B COASY CSNK2A1 CSNK2B CYB5R3 DEPTOR DPPA4 EEF2K EIF3B EIF3F EIF4B EIF4EBP1 EP300 FBXO7 GDI2P1 GRIA1 HTT IRS1 KAT2B KIR3DL1 LYN MAPK1 MAPK3 MAPK8 MAPK9 MAPT MARK2 MTOR MXD1 NCBP1 NEDD4 NEK6 NR1I2 PDK1 PDPK1 PIK3CA PIN1 PIP4K2A POLDIP3 PPP1R9A PPP1R9B PPP2CA RAC1 RBX1 RHEB RPS6 RPTOR SRC STK11 SYK TBK1 TERT TRAF4 URI1 USP11 XPO1	112 interacting genes: AKT1 AMFR AP2A2 BDKRB1 CASP1 CASP3 CASP6 CBS CEP126 CHD3 CHUK CREBBP CRMP1 CTBP1 DLG4 DNALI1 DPPA4 DUSP10 ECH1 EGFR ELP1 ERCC6L ETV4 EVL F8A1 FEZ1 FICD FTL GAPDH GGA2 GIT1 GOLPH3L GPRASP2 GRB2 H2AP H3C10 HAP1 HEYL HIP1 HIP1R HOXC11 HOXC4 HSP90AA1 HSPA8 HYPK IFT20 IFT57 IKBKB ING5 KAT2B MAGEA3 MAGEB18 MAGEB6 MAP3K10 MBD1 MED21 MED31 MID1 MRFAP1 MRFAP1L1 MTSS1 NCOR1 NUP58 OPTN OSTF1 PACSIN1 PDK2 PEX11B PFN2 PIAS1 PIAS4 PIK3R1 PML PPP2CA PRPF40A PRPF40B PSMC5 PSME4 RASA1 REST RHEB RNF20 RPS6KB1 SAP30 SETD2 SH3GL3 SH3GLB1 SIN3A SP1 SUMO1 SYMPK TACC1 TAF4 TBP TCERG1 TGM2 TP53 TPR TRAFD1 TRIP10 TTC23 TUBB UBAC1 UBE2E3 UBE2K UTP14A VCP XRCC6 ZDHHC17 ZFYVE19 ZNF451 ZNF655
Entrez ID		6198	3064
HPRD ID		10202	00883
Ensembl ID		ENSG00000108443	ENSG00000197386
Uniprot IDs		P23443	P42858
PDB IDs		3A60 3A61 3A62 3WE4 3WF5 3WF6 3WF7 3WF8 3WF9 4L3J 4L3L 4L42 4L43 4L44 4L45 4L46 4RLO 4RLP 5WBH 5WBK	2D3X 2LD0 2LD2 3IO4 3IO6 3IOR 3IOT 3IOU 3IOV 3IOW 3LRH 4FE8 4FEB 4FEC 4FED 4RAV 6EZ8 6N8C 6RMH 6X9O 6YEJ
Enriched GO Terms of Interacting Partners?
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