RPS6KB1 and PIP4K2A

Number of citations of the paper that reports this interaction (PubMedID 12747804)
11

Data Source:
BioGRID (enzymatic study)

		RPS6KB1	PIP4K2A
Description		ribosomal protein S6 kinase B1	phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Neuron Projection Synapse	Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleoplasm Lysosome Autophagosome Cytosol Plasma Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidylinositol-5-phosphate 4-kinase Activity Protein Homodimerization Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Apoptotic Process Signal Transduction Peptidyl-serine Phosphorylation Response To Nutrient Levels TOR Signaling Cellular Response To Insulin Stimulus Negative Regulation Of Apoptotic Process Long-chain Fatty Acid Import Into Cell Positive Regulation Of Translation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Translational Initiation Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Cellular Response To Growth Factor Stimulus	Regulation Of Autophagy Phosphorylation Megakaryocyte Development Negative Regulation Of Insulin Receptor Signaling Pathway Autophagosome-lysosome Fusion Vesicle-mediated Cholesterol Transport Negative Regulation Of 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Biosynthetic Process Positive Regulation Of Autophagosome Assembly
Pathways		mTORC1-mediated signalling	Synthesis of PIPs at the plasma membrane PI5P Regulates TP53 Acetylation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Synthesis of PIPs in the nucleus
Drugs
Diseases
GWAS		Body shape index ( 34021172) C-reactive protein levels ( 30388399) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia or multiple sclerosis ( 31407831) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088) Obesity-related traits ( 23251661) Triglycerides ( 30275531)	Acute lymphoblastic leukemia (B-cell precursor) ( 23996088) Acute lymphoblastic leukemia (childhood) ( 29348612) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) B-cell acute lymphoblastic leukaemia ( 31767839) Height ( 31562340) Lymphocyte percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Positive urgency ( 30718321) Severe influenza A (H1N1) infection ( 26379185)
Interacting Genes		62 interacting genes: ACTA1 AKT1 APP BTK CDC42 CDK1 CLEC3B COASY CSNK2A1 CSNK2B CYB5R3 DEPTOR DPPA4 EEF2K EIF3B EIF3F EIF4B EIF4EBP1 EP300 FBXO7 GDI2P1 GRIA1 HTT IRS1 KAT2B KIR3DL1 LYN MAPK1 MAPK3 MAPK8 MAPK9 MAPT MARK2 MTOR MXD1 NCBP1 NEDD4 NEK6 NR1I2 PDK1 PDPK1 PIK3CA PIN1 PIP4K2A POLDIP3 PPP1R9A PPP1R9B PPP2CA RAC1 RBX1 RHEB RPS6 RPTOR SRC STK11 SYK TBK1 TERT TRAF4 URI1 USP11 XPO1	7 interacting genes: BTK GSTK1 MEIS3 ODAD2 RAC1 RPS6KB1 TEC
Entrez ID		6198	5305
HPRD ID		10202	11931
Ensembl ID		ENSG00000108443	ENSG00000150867
Uniprot IDs		P23443	P48426
PDB IDs		3A60 3A61 3A62 3WE4 3WF5 3WF6 3WF7 3WF8 3WF9 4L3J 4L3L 4L42 4L43 4L44 4L45 4L46 4RLO 4RLP 5WBH 5WBK	2YBX 6OSP 6UX9
Enriched GO Terms of Interacting Partners?
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