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NCBP1 and NUP214
NCBP1
NUP214
Description
nuclear cap binding protein subunit 1
nucleoporin 214
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Mitochondrion
Cytosol
MRNA Cap Binding Complex
Nuclear Cap Binding Complex
RNA Cap Binding Complex
Ribonucleoprotein Complex
Nuclear Pore
Nucleoplasm
Cytosol
Cytoplasmic Side Of Nuclear Pore
Molecular Function
RNA Cap Binding
RNA 7-methylguanosine Cap Binding
RNA Binding
MRNA Binding
Protein Binding
Nuclear Export Signal Receptor Activity
Protein Binding
Nuclear Localization Sequence Binding
Structural Constituent Of Nuclear Pore
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Spliceosomal Complex Assembly
7-methylguanosine MRNA Capping
RNA Catabolic Process
MRNA Export From Nucleus
Regulation Of Translational Initiation
RNA Splicing
Positive Regulation Of Cell Growth
Gene Silencing By RNA
Positive Regulation Of MRNA 3'-end Processing
MRNA Cis Splicing, Via Spliceosome
Positive Regulation Of MRNA Splicing, Via Spliceosome
Regulation Of MRNA Processing
Pre-mRNA Cleavage Required For Polyadenylation
Regulation Of MRNA Polyadenylation
Positive Regulation Of RNA Binding
Mitotic Cell Cycle
RNA Export From Nucleus
MRNA Export From Nucleus
Protein Import Into Nucleus
Protein Export From Nucleus
Regulation Of Nucleocytoplasmic Transport
Regulation Of Cell Cycle
Pathways
SLBP independent Processing of Histone Pre-mRNAs
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Transport of the SLBP independent Mature mRNA
Transport of the SLBP Dependant Mature mRNA
Transport of Mature mRNA Derived from an Intronless Transcript
Transport of Mature mRNA derived from an Intron-Containing Transcript
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
Formation of HIV-1 elongation complex containing HIV-1 Tat
Abortive elongation of HIV-1 transcript in the absence of Tat
snRNP Assembly
RNA Polymerase II Pre-transcription Events
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
mRNA 3'-end processing
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription Termination
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
Processing of Intronless Pre-mRNAs
Signaling by FGFR2 IIIa TM
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
ISG15 antiviral mechanism
Transport of the SLBP independent Mature mRNA
Transport of the SLBP Dependant Mature mRNA
Transport of Mature mRNA Derived from an Intronless Transcript
Transport of Mature mRNA derived from an Intron-Containing Transcript
Rev-mediated nuclear export of HIV RNA
Transport of Ribonucleoproteins into the Host Nucleus
NS1 Mediated Effects on Host Pathways
Viral Messenger RNA Synthesis
NEP/NS2 Interacts with the Cellular Export Machinery
Regulation of Glucokinase by Glucokinase Regulatory Protein
Nuclear import of Rev protein
Vpr-mediated nuclear import of PICs
snRNP Assembly
SUMOylation of DNA damage response and repair proteins
SUMOylation of ubiquitinylation proteins
Nuclear Pore Complex (NPC) Disassembly
Regulation of HSF1-mediated heat shock response
SUMOylation of SUMOylation proteins
HuR (ELAVL1) binds and stabilizes mRNA
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA replication proteins
Transcriptional regulation by small RNAs
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
tRNA processing in the nucleus
HCMV Early Events
HCMV Late Events
Drugs
Diseases
GWAS
Thyroid cancer (Papillary, radiation-related) (
20350937
)
Aspartate aminotransferase levels (
31219225
)
Interacting Genes
19 interacting genes:
BNIP1
BNIP2
BNIP3
EIF4G1
EIF4G2
HNRNPF
HNRNPH1
LINC01554
NCBP2
NUP214
PSTPIP1
PTEN
RNF20
RNF40
RPS6KB1
SELENOS
SNRPA1
STAU1
ZDHHC17
31 interacting genes:
APC
ASS1
CHST6
CLEC4G
DDX19B
DYNC1I1
IPO5
LSS
MRPS6
NCBP1
NFX1
NUP107
NUP42
NUP62
NUP88
NUP98
NXF1
NXF2
POMT1
PRRX2
SMAD2
SMAD3
SMAD4
STOM
SUMO2
TNPO1
VAV2
XPO1
XPO5
XPOT
ZFP36
Entrez ID
4686
8021
HPRD ID
02717
00258
Ensembl ID
ENSG00000136937
ENSG00000126883
Uniprot IDs
A0A024R179
Q09161
B7ZAV2
P35658
PDB IDs
1H2T
1H2U
1H2V
1H6K
1N52
1N54
3FEX
3FEY
5OO6
5OOB
6D0Y
7ABG
2OIT
3FHC
3FMO
3FMP
5DIS
Enriched GO Terms of Interacting Partners
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