LIPC and LRP1

Number of citations of the paper that reports this interaction (PubMedID 7721852)
19

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		LIPC	LRP1
Description		lipase C, hepatic type	LDL receptor related protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen High-density Lipoprotein Particle	Nucleus Lysosomal Membrane Early Endosome Golgi Apparatus Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Pit Focal Adhesion Membrane Basolateral Plasma Membrane Clathrin-coated Vesicle Dendrite Endocytic Vesicle Membrane Insulin-responsive Compartment Neuronal Cell Body Receptor Complex Axonal Growth Cone Apical Part Of Cell Plasma Membrane Protein Complex
	Molecular Function	Lipoprotein Lipase Activity Phospholipase Activity Lysophospholipase Activity Triglyceride Lipase Activity Heparin Binding Phospholipase A1 Activity Lipase Activity Low-density Lipoprotein Particle Binding Apolipoprotein Binding Phosphatidylserine 1-acylhydrolase Activity 1-acyl-2-lysophosphatidylserine Acylhydrolase Activity Phosphatidyl Phospholipase B Activity	Amyloid-beta Binding Protease Binding RNA Binding Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Calcium Ion Binding Protein Binding Coreceptor Activity Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Clathrin Heavy Chain Binding Apolipoprotein Binding Signaling Receptor Activity Cargo Receptor Activity Heparan Sulfate Proteoglycan Binding Protein-containing Complex Binding Lipoprotein Particle Receptor Binding
	Biological Process	Fatty Acid Biosynthetic Process Cholesterol Metabolic Process Lipid Catabolic Process Triglyceride Catabolic Process Very-low-density Lipoprotein Particle Remodeling Intermediate-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Chylomicron Remnant Clearance Phosphatidylcholine Catabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Triglyceride Homeostasis	Retinoid Metabolic Process Astrocyte Activation Involved In Immune Response Lipid Metabolic Process Receptor-mediated Endocytosis Phagocytosis Lysosomal Transport Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Aging Cell Population Proliferation Negative Regulation Of Gene Expression Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Cholesterol Efflux Positive Regulation Of Cell Death Negative Regulation Of Neuron Projection Development Negative Regulation Of Smooth Muscle Cell Migration Cerebral Cortex Development Negative Regulation Of Wnt Signaling Pathway Receptor Internalization Positive Regulation Of Protein Binding Positive Regulation Of Lipid Transport Regulation Of Cholesterol Transport Regulation Of Phospholipase A2 Activity Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Aorta Morphogenesis Lipoprotein Metabolic Process Lipoprotein Transport Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Cellular Lipid Catabolic Process Transcytosis Positive Regulation Of Endocytosis Positive Regulation Of Axon Extension Involved In Regeneration Positive Regulation Of Collateral Sprouting Of Injured Axon Positive Regulation Of Phagocytosis Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Focal Adhesion Assembly Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Chemoattraction Of Axon Positive Regulation Of ERK1 And ERK2 Cascade Amyloid-beta Clearance Amyloid-beta Clearance By Transcytosis Amyloid-beta Clearance By Cellular Catabolic Process Transport Across Blood-brain Barrier Positive Regulation Of Schwann Cell Migration Positive Regulation Of Amyloid-beta Clearance Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cholesterol Import Positive Regulation Of Transcytosis Cellular Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Metallopeptidase Activity Positive Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		Assembly of active LPL and LIPC lipase complexes Chylomicron clearance	Scavenging of heme from plasma Retinoid metabolism and transport
Drugs			Antihemophilic factor, human recombinant Tenecteplase Coagulation Factor IX (Recombinant) Lanoteplase Coagulation Factor IX Human Lonoctocog alfa Moroctocog alfa
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385826 23455636 21665990) Alanine aminotransferase levels ( 33547301 34315874) Alzheimer's disease (cognitive decline) ( 23535033) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Amyotrophic lateral sclerosis ( 18084291) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301 34315874) Blood metabolite levels ( 24816252) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cardiovascular disease risk factors ( 21943158) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Cholesterol efflux capacity ( 30369316) Cholesterol, total ( 24097068 19060911 25961943 20686565 26582766) Cognitive performance ( 20125193) Eosinophil counts ( 32888494) Gout ( 22179738) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol ( 24097068 29404214 18193043 18193044 20864672 26160806 19060906 23505323 19060910 19060911 21347282 25961943 26780889 20686565 26582766) HDL cholesterol levels ( 32203549 31694877 28334899 26690388 31087446 32759990 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels in HIV infection ( 33109212) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Hematocrit ( 32888494) Hematological and biochemical traits ( 20139978) Hemoglobin ( 32888494) High density lipoprotein cholesterol levels ( 30718733 33499410 31211820 29403010 33339817 29615537) Ischemic stroke ( 26089329) LDL cholesterol levels ( 32203549) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Lipid metabolism phenotypes ( 22286219 19936222) Lipid traits ( 24386095 24023260) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 29403010) Lymphocyte counts ( 32888494) Lysophosphatidylethanolamine levels ( 31551469) Metabolic syndrome ( 22399527 30382898 31589552) Metabolic syndrome (bivariate traits) ( 21386085) Metabolite levels ( 23281178 23823483 22916037 19043545) Metabolite levels (lipoprotein measures) ( 27005778) Non-small cell lung cancer ( 23144319) Obesity-related traits ( 23251661) Phosphatidylethanolamine levels ( 31551469) Phospholipid levels (plasma) ( 22359512) Postprandial triglyceride response ( 32603185) Red blood cell count ( 32888494) Red blood cell traits ( 23222517) Schizophrenia ( 26198764) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 31636271 33031748) Serum metabolite levels (CMS) ( 31636271) Stroke ( 26089329) Total cholesterol levels ( 28334899 29403010 33339817 29615537) Triglyceride levels ( 32203549 28334899 31087446 29403010 33339817 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels in HIV infection ( 33109212) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068 18193043 30275531 25961943 20686565 26582766) Tumor necrosis factor levels ( 32805626)	Abdominal aortic aneurysm ( 27899403 22055160) Adult asthma ( 30787307) Asthma ( 31959851 27182965 31619474 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 28552196) Cervical artery dissection ( 25420145) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) HDL cholesterol ( 24097068 20686565) HDL cholesterol levels ( 28334899) Headache ( 29397368) Height ( 31562340) Itch intensity from mosquito bite ( 28199695) Lung function (FEV1/FVC) ( 30804560) Medication use (anilides) ( 31015401) Medication use (antimigraine preparations) ( 31015401) Migraine ( 22683712 27182965 23793025 21666692 27322543) Migraine - clinic-based ( 23793025) Migraine without aura ( 23793025 27322543) Moyamoya disease ( 29273593) Peak expiratory flow ( 30804560) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Pulse pressure ( 30578418) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Spontaneous coronary artery dissection ( 32887874 32374345) Triglyceride levels ( 28334899) Triglycerides ( 24097068 25961943 20686565)
Interacting Genes		3 interacting genes: ADHFE1 APOB LRP1	76 interacting genes: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 BDNF C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CCN2 CD82 CLU CSRP2 CTSG DAB1 DAB2 DLG4 EGFR ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90AA1 HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 MTDH NAB2 NGF NOS1AP NTF3 NTF4 PDGFB PID1 PIGA PLAT PLAUR PMEL PRKACA PTPN11 RIC8B SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A
Entrez ID		3990	4035
HPRD ID		01058	00138
Ensembl ID		ENSG00000166035	ENSG00000123384
Uniprot IDs		A6H8L5 P11150	Q07954 Q59FG2
PDB IDs			1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY
Enriched GO Terms of Interacting Partners?
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