LRP1 and MMP13

Number of citations of the paper that reports this interaction (PubMedID 10514495)
35

Data Source:
HPRD (in vitro, in vivo)

		LRP1	MMP13
Description		LDL receptor related protein 1	matrix metallopeptidase 13
Image
GO Annotations	Cellular Component	Nucleus Lysosomal Membrane Early Endosome Golgi Apparatus Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Pit Focal Adhesion Membrane Basolateral Plasma Membrane Clathrin-coated Vesicle Dendrite Endocytic Vesicle Membrane Insulin-responsive Compartment Neuronal Cell Body Receptor Complex Axonal Growth Cone Apical Part Of Cell Plasma Membrane Protein Complex	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Amyloid-beta Binding Protease Binding RNA Binding Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Calcium Ion Binding Protein Binding Coreceptor Activity Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Clathrin Heavy Chain Binding Apolipoprotein Binding Signaling Receptor Activity Cargo Receptor Activity Heparan Sulfate Proteoglycan Binding Protein-containing Complex Binding Lipoprotein Particle Receptor Binding	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Collagen Binding Zinc Ion Binding
	Biological Process	Retinoid Metabolic Process Astrocyte Activation Involved In Immune Response Lipid Metabolic Process Receptor-mediated Endocytosis Phagocytosis Lysosomal Transport Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Aging Cell Population Proliferation Negative Regulation Of Gene Expression Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Cholesterol Efflux Positive Regulation Of Cell Death Negative Regulation Of Neuron Projection Development Negative Regulation Of Smooth Muscle Cell Migration Cerebral Cortex Development Negative Regulation Of Wnt Signaling Pathway Receptor Internalization Positive Regulation Of Protein Binding Positive Regulation Of Lipid Transport Regulation Of Cholesterol Transport Regulation Of Phospholipase A2 Activity Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Aorta Morphogenesis Lipoprotein Metabolic Process Lipoprotein Transport Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Cellular Lipid Catabolic Process Transcytosis Positive Regulation Of Endocytosis Positive Regulation Of Axon Extension Involved In Regeneration Positive Regulation Of Collateral Sprouting Of Injured Axon Positive Regulation Of Phagocytosis Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Focal Adhesion Assembly Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Chemoattraction Of Axon Positive Regulation Of ERK1 And ERK2 Cascade Amyloid-beta Clearance Amyloid-beta Clearance By Transcytosis Amyloid-beta Clearance By Cellular Catabolic Process Transport Across Blood-brain Barrier Positive Regulation Of Schwann Cell Migration Positive Regulation Of Amyloid-beta Clearance Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cholesterol Import Positive Regulation Of Transcytosis Cellular Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Metallopeptidase Activity Positive Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Endochondral Ossification Growth Plate Cartilage Development Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Bone Mineralization Collagen Catabolic Process Cellular Protein Metabolic Process Bone Morphogenesis Response To Amyloid-beta
Pathways		Scavenging of heme from plasma Retinoid metabolism and transport	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures RUNX2 regulates genes involved in cell migration
Drugs		Antihemophilic factor, human recombinant Tenecteplase Coagulation Factor IX (Recombinant) Lanoteplase Coagulation Factor IX Human Lonoctocog alfa Moroctocog alfa	Marimastat 3-Methylpyridine 2-{4-[4-(4-Chloro-Phenoxy)-Benzenesulfonyl]-Tetrahydro-Pyran-4-Yl}-N-Hydroxy-Acetamide WAY-151693 Hydroxyaminovaline 4-methoxybenzenesulfinate PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-(3-METHYL-BENZYLAMIDE) PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-(4-FLUORO-3-METHYL-BENZYLAMIDE) PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-[(PYRIDIN-3-YLMETHYL)-AMIDE] Endostatin TERT-BUTYL 4-({[4-(BUT-2-YN-1-YLAMINO)PHENYL]SULFONYL}METHYL)-4-[(HYDROXYAMINO)CARBONYL]PIPERIDINE-1-CARBOXYLATE 4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID 5-(2-ETHOXYETHYL)-5-[4-(4-FLUOROPHENOXY)PHENOXY]PYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE CTS-1027 BENZYL 6-BENZYL-5,7-DIOXO-6,7-DIHYDRO-5H-[1,3]THIAZOLO[3,2-C]PYRIMIDINE-2-CARBOXYLATE
Diseases
GWAS		Abdominal aortic aneurysm ( 27899403 22055160) Adult asthma ( 30787307) Asthma ( 31959851 27182965 31619474 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 28552196) Cervical artery dissection ( 25420145) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) HDL cholesterol ( 24097068 20686565) HDL cholesterol levels ( 28334899) Headache ( 29397368) Height ( 31562340) Itch intensity from mosquito bite ( 28199695) Lung function (FEV1/FVC) ( 30804560) Medication use (anilides) ( 31015401) Medication use (antimigraine preparations) ( 31015401) Migraine ( 22683712 27182965 23793025 21666692 27322543) Migraine - clinic-based ( 23793025) Migraine without aura ( 23793025 27322543) Moyamoya disease ( 29273593) Peak expiratory flow ( 30804560) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Pulse pressure ( 30578418) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Spontaneous coronary artery dissection ( 32887874 32374345) Triglyceride levels ( 28334899) Triglycerides ( 24097068 25961943 20686565)	Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Diisocyanate-induced asthma ( 25918132) Peanut allergy ( 29030101)
Interacting Genes		76 interacting genes: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 BDNF C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CCN2 CD82 CLU CSRP2 CTSG DAB1 DAB2 DLG4 EGFR ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90AA1 HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 MTDH NAB2 NGF NOS1AP NTF3 NTF4 PDGFB PID1 PIGA PLAT PLAUR PMEL PRKACA PTPN11 RIC8B SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A	10 interacting genes: ACSL3 ADAMTS5 BCAN CCL7 COL2A1 F12 FBXO7 LRP1 MMP14 TIMP3
Entrez ID		4035	4322
HPRD ID		00138	02522
Ensembl ID		ENSG00000123384	ENSG00000137745
Uniprot IDs		Q07954 Q59FG2	P45452 Q53H33
PDB IDs		1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY	1EUB 1FLS 1FM1 1PEX 1UC1 1XUC 1XUD 1XUR 1YOU 1ZTQ 2D1N 2E2D 2OW9 2OZR 2PJT 2YIG 3ELM 3I7G 3I7I 3KEC 3KEJ 3KEK 3KRY 3LJZ 3O2X 3TVC 3WV1 3WV2 3WV3 3ZXH 456C 4A7B 4FU4 4FVL 4G0D 4JP4 4JPA 4L19 5B5O 5B5P 5BOT 5BOY 5BPA 5UWK 5UWL 5UWM 5UWN 830C
Enriched GO Terms of Interacting Partners?
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