LIPC

Description		lipase C, hepatic type
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen High-density Lipoprotein Particle
	Molecular Function	Lipoprotein Lipase Activity Phospholipase Activity Lysophospholipase Activity Triglyceride Lipase Activity Heparin Binding Phospholipase A1 Activity Lipase Activity Low-density Lipoprotein Particle Binding Apolipoprotein Binding Phosphatidylserine 1-acylhydrolase Activity 1-acyl-2-lysophosphatidylserine Acylhydrolase Activity Phosphatidyl Phospholipase B Activity
	Biological Process	Fatty Acid Biosynthetic Process Cholesterol Metabolic Process Lipid Catabolic Process Triglyceride Catabolic Process Very-low-density Lipoprotein Particle Remodeling Intermediate-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Chylomicron Remnant Clearance Phosphatidylcholine Catabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Triglyceride Homeostasis
Pathways		Assembly of active LPL and LIPC lipase complexes Chylomicron clearance
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385826 23455636 21665990) Alanine aminotransferase levels ( 33547301 34315874) Alzheimer's disease (cognitive decline) ( 23535033) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Amyotrophic lateral sclerosis ( 18084291) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301 34315874) Blood metabolite levels ( 24816252) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cardiovascular disease risk factors ( 21943158) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Cholesterol efflux capacity ( 30369316) Cholesterol, total ( 24097068 19060911 25961943 20686565 26582766) Cognitive performance ( 20125193) Eosinophil counts ( 32888494) Gout ( 22179738) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol ( 24097068 29404214 18193043 18193044 20864672 26160806 19060906 23505323 19060910 19060911 21347282 25961943 26780889 20686565 26582766) HDL cholesterol levels ( 32203549 31694877 28334899 26690388 31087446 32759990 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels in HIV infection ( 33109212) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Hematocrit ( 32888494) Hematological and biochemical traits ( 20139978) Hemoglobin ( 32888494) High density lipoprotein cholesterol levels ( 30718733 33499410 31211820 29403010 33339817 29615537) Ischemic stroke ( 26089329) LDL cholesterol levels ( 32203549) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Lipid metabolism phenotypes ( 22286219 19936222) Lipid traits ( 24386095 24023260) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 29403010) Lymphocyte counts ( 32888494) Lysophosphatidylethanolamine levels ( 31551469) Metabolic syndrome ( 22399527 30382898 31589552) Metabolic syndrome (bivariate traits) ( 21386085) Metabolite levels ( 23281178 23823483 22916037 19043545) Metabolite levels (lipoprotein measures) ( 27005778) Non-small cell lung cancer ( 23144319) Obesity-related traits ( 23251661) Phosphatidylethanolamine levels ( 31551469) Phospholipid levels (plasma) ( 22359512) Postprandial triglyceride response ( 32603185) Red blood cell count ( 32888494) Red blood cell traits ( 23222517) Schizophrenia ( 26198764) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 31636271 33031748) Serum metabolite levels (CMS) ( 31636271) Stroke ( 26089329) Total cholesterol levels ( 28334899 29403010 33339817 29615537) Triglyceride levels ( 32203549 28334899 31087446 29403010 33339817 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels in HIV infection ( 33109212) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068 18193043 30275531 25961943 20686565 26582766) Tumor necrosis factor levels ( 32805626)
Interacting Genes		3 interacting genes: ADHFE1 APOB LRP1
Entrez ID		3990
HPRD ID		01058
Ensembl ID		ENSG00000166035
Uniprot IDs		A6H8L5 P11150
PDB IDs
Enriched GO Terms of Interacting Partners?
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