LIPC and ADHFE1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		LIPC	ADHFE1
Description		lipase C, hepatic type	alcohol dehydrogenase iron containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen High-density Lipoprotein Particle	Mitochondrion Mitochondrial Matrix
	Molecular Function	Lipoprotein Lipase Activity Phospholipase Activity Lysophospholipase Activity Triglyceride Lipase Activity Heparin Binding Phospholipase A1 Activity Lipase Activity Low-density Lipoprotein Particle Binding Apolipoprotein Binding Phosphatidylserine 1-acylhydrolase Activity 1-acyl-2-lysophosphatidylserine Acylhydrolase Activity Phosphatidyl Phospholipase B Activity	Alcohol Dehydrogenase (NAD+) Activity Metal Ion Binding Hydroxyacid-oxoacid Transhydrogenase Activity
	Biological Process	Fatty Acid Biosynthetic Process Cholesterol Metabolic Process Lipid Catabolic Process Triglyceride Catabolic Process Very-low-density Lipoprotein Particle Remodeling Intermediate-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Chylomicron Remnant Clearance Phosphatidylcholine Catabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Triglyceride Homeostasis	2-oxoglutarate Metabolic Process Glutamate Catabolic Process Via 2-oxoglutarate
Pathways		Assembly of active LPL and LIPC lipase complexes Chylomicron clearance	Interconversion of 2-oxoglutarate and 2-hydroxyglutarate
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385826 23455636 21665990) Alanine aminotransferase levels ( 33547301 34315874) Alzheimer's disease (cognitive decline) ( 23535033) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Amyotrophic lateral sclerosis ( 18084291) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301 34315874) Blood metabolite levels ( 24816252) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cardiovascular disease risk factors ( 21943158) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Cholesterol efflux capacity ( 30369316) Cholesterol, total ( 24097068 19060911 25961943 20686565 26582766) Cognitive performance ( 20125193) Eosinophil counts ( 32888494) Gout ( 22179738) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol ( 24097068 29404214 18193043 18193044 20864672 26160806 19060906 23505323 19060910 19060911 21347282 25961943 26780889 20686565 26582766) HDL cholesterol levels ( 32203549 31694877 28334899 26690388 31087446 32759990 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels in HIV infection ( 33109212) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Hematocrit ( 32888494) Hematological and biochemical traits ( 20139978) Hemoglobin ( 32888494) High density lipoprotein cholesterol levels ( 30718733 33499410 31211820 29403010 33339817 29615537) Ischemic stroke ( 26089329) LDL cholesterol levels ( 32203549) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Lipid metabolism phenotypes ( 22286219 19936222) Lipid traits ( 24386095 24023260) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 29403010) Lymphocyte counts ( 32888494) Lysophosphatidylethanolamine levels ( 31551469) Metabolic syndrome ( 22399527 30382898 31589552) Metabolic syndrome (bivariate traits) ( 21386085) Metabolite levels ( 23281178 23823483 22916037 19043545) Metabolite levels (lipoprotein measures) ( 27005778) Non-small cell lung cancer ( 23144319) Obesity-related traits ( 23251661) Phosphatidylethanolamine levels ( 31551469) Phospholipid levels (plasma) ( 22359512) Postprandial triglyceride response ( 32603185) Red blood cell count ( 32888494) Red blood cell traits ( 23222517) Schizophrenia ( 26198764) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 31636271 33031748) Serum metabolite levels (CMS) ( 31636271) Stroke ( 26089329) Total cholesterol levels ( 28334899 29403010 33339817 29615537) Triglyceride levels ( 32203549 28334899 31087446 29403010 33339817 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels in HIV infection ( 33109212) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068 18193043 30275531 25961943 20686565 26582766) Tumor necrosis factor levels ( 32805626)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252)
Interacting Genes		3 interacting genes: ADHFE1 APOB LRP1	2 interacting genes: GNAQ LIPC
Entrez ID		3990	137872
HPRD ID		01058	12428
Ensembl ID		ENSG00000166035	ENSG00000147576
Uniprot IDs		A6H8L5 P11150	Q8IWW8
PDB IDs
Enriched GO Terms of Interacting Partners?
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