Description |
insulin receptor substrate 1 |
regulatory associated protein of MTOR complex 1 |
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GO Annotations |
Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
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Diseases |
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GWAS |
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- Adult body size ( 32376654)
- Airway responsiveness in chronic obstructive pulmonary disease ( 25514360)
- Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
- Bipolar disorder ( 31043756)
- Body mass index ( 28892062 25673413)
- Body size at age 10 ( 32376654)
- Hypertension ( 30487518)
- Mean arterial pressure ( 30487518)
- NASH resolution in nonalcoholic steatohepatitis ( 31832568)
- Nicotine dependence symptom count ( 25555482)
- Obesity ( 23563607)
- Pulse pressure ( 29403010 30487518)
- Systolic blood pressure ( 30487518)
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Interacting Genes |
81 interacting genes:
AKT1
ALK
AP3S1
APP
ATP2A1
ATP2A2
ATP2A3
BCL2L1
BCR
CAV1
CDH1
CHUK
CRK
CSNK2A1
CSNK2B
EGFR
ERBB2
FBXO25
FBXW8
FER
FES
FYN
GHR
GRB10
GRB14
GRB2
IGF1R
IKBKB
IL4R
INSR
JAK1
JAK2
JAK3
MAPK1
MAPK3
MAPK8
MAPK9
MTOR
NCK2
NEDD4
NPM1
NRDC
NTRK1
NUMB
PASK
PDPK1
PELI1
PHIP
PIK3R1
PIK3R2
PIK3R3
PLCG2
PRKCD
PRKCG
PRKCQ
PRKCZ
PTK2
PTPN1
PTPN11
PTPRC
PTPRD
PTPRF
PTPRU
RAD51
ROCK1
RPS6KB1
RPTOR
SHC1
SIK2
SOCS1
SOCS3
TERT
TRIM72
TUB
TYK2
UBC
UBTF
YWHAB
YWHAE
YWHAG
YWHAZ
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30 interacting genes:
BAHCC1
CBX8
CCDC40
CILK1
DCXR
DUXAP9
EIF4EBP1
EIF4EBP2
IRS1
IRS2
LINC00839
MAPK1
MAPK3
MARK4
MLST8
MTOR
NRBF2
PLD2
PRKAA1
PRKAA2
RAP1B
RHEB
RNF213
RPS6KA1
RPS6KB1
RRAGB
TNRC6C
USP36
WDR45B
WIPI2
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Entrez ID |
3667 |
57521 |
HPRD ID |
00943 |
06184 |
Ensembl ID |
ENSG00000169047
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ENSG00000141564
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Uniprot IDs |
P35568
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Q6DKI0
Q8N122
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PDB IDs |
1IRS
1K3A
1QQG
2Z8C
5U1M
6BNT
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5H64
6BCU
6BCX
6SB0
6SB2
6U62
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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