RPTOR and RNF213

		RPTOR	RNF213
Description		regulatory associated protein of MTOR complex 1	ring finger protein 213
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Cytoplasmic Stress Granule Dendrite TORC1 Complex Neuronal Cell Body	Nucleolus Cytoplasm Cytosol Membrane
	Molecular Function	RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding TFIIIC-class Transcription Factor Complex Binding Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Kinase Activator Activity Protein-macromolecule Adaptor Activity Protein-containing Complex Binding 14-3-3 Protein Binding	Ubiquitin-protein Transferase Activity ATP Hydrolysis Activity Metal Ion Binding
	Biological Process	Regulation Of Cell Growth Positive Regulation Of Endothelial Cell Proliferation Regulation Of Cell Size Cellular Response To Starvation Response To Xenobiotic Stimulus Regulation Of Autophagy Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Activation Of Protein Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Social Behavior TORC1 Signaling Negative Regulation Of Catalytic Activity Positive Regulation Of Transcription By RNA Polymerase III Cellular Response To Amino Acid Stimulus Cellular Response To Leucine Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Angiogenesis Sprouting Angiogenesis Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Homooligomerization Protein Autoubiquitination Negative Regulation Of Non-canonical Wnt Signaling Pathway
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	Suppression of apoptosis Signaling by ALK fusions and activated point mutants Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Body mass index ( 28892062 25673413) Body size at age 10 ( 32376654) Hypertension ( 30487518) Mean arterial pressure ( 30487518) NASH resolution in nonalcoholic steatohepatitis ( 31832568) Nicotine dependence symptom count ( 25555482) Obesity ( 23563607) Pulse pressure ( 29403010 30487518) Systolic blood pressure ( 30487518)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Aspartate aminotransferase levels ( 33547301) Coronary artery disease ( 33020668) Hypertension ( 32709000) Lipoprotein-associated phospholipase A2 activity change in response to statin therapy ( 23118302) Migraine ( 27182965 27322543) Moyamoya disease ( 21048783 29273593)
Interacting Genes		30 interacting genes: BAHCC1 CBX8 CCDC40 CILK1 DCXR DUXAP9 EIF4EBP1 EIF4EBP2 IRS1 IRS2 LINC00839 MAPK1 MAPK3 MARK4 MLST8 MTOR NRBF2 PLD2 PRKAA1 PRKAA2 RAP1B RHEB RNF213 RPS6KA1 RPS6KB1 RRAGB TNRC6C USP36 WDR45B WIPI2	14 interacting genes: GOLGA2 KRT40 MTDH PLAC9 REL RPTOR SUMO2 TRIM23 TRIM27 TRIP6 UBE2D2 UBE2D3 UBE2L3 UBXN11
Entrez ID		57521	57674
HPRD ID		06184	10716
Ensembl ID		ENSG00000141564	ENSG00000173821
Uniprot IDs		Q6DKI0 Q8N122	A0A0A0MTC1 A0A0A0MTR7 Q63HN8
PDB IDs		5H64 6BCU 6BCX 6SB0 6SB2 6U62
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?