RPTOR and RHEB

  • Number of citations of the paper that reports this interaction (PubMedID 15854902)
  • 391
  • Data Source:
  • BioGRID (imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology)
  • HPRD (in vitro, in vivo)

RPTOR

RHEB

Description regulatory associated protein of MTOR complex 1 Ras homolog, mTORC1 binding
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Adult body size ( 32376654)
  • Airway responsiveness in chronic obstructive pulmonary disease ( 25514360)
  • Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
  • Bipolar disorder ( 31043756)
  • Body mass index ( 28892062 25673413)
  • Body size at age 10 ( 32376654)
  • Hypertension ( 30487518)
  • Mean arterial pressure ( 30487518)
  • NASH resolution in nonalcoholic steatohepatitis ( 31832568)
  • Nicotine dependence symptom count ( 25555482)
  • Obesity ( 23563607)
  • Pulse pressure ( 29403010 30487518)
  • Systolic blood pressure ( 30487518)
  • Carboplatin disposition in epthelial ovarian cancer ( 29367611)
  • Metabolite levels ( 23823483)
Interacting Genes 30 interacting genes: BAHCC1 CBX8 CCDC40 CILK1 DCXR DUXAP9 EIF4EBP1 EIF4EBP2 IRS1 IRS2 LINC00839 MAPK1 MAPK3 MARK4 MLST8 MTOR NRBF2 PLD2 PRKAA1 PRKAA2 RAP1B RHEB RNF213 RPS6KA1 RPS6KB1 RRAGB TNRC6C USP36 WDR45B WIPI2 35 interacting genes: A2M APOE APPBP2 ARIH2 ATM ATR BNIP3 BNIP3L BRAF CENPE CREB3 ECSIT FKBP8 HTT MAPK15 MTOR NCAM1 NOS3 PDE6D PIGB PLD1 PPP1R3C PSEN1 PSEN2 PTPRN2 RABAC1 RAF1 RNF152 RPS6KB1 RPTOR TRIM55 TRIM63 TSC1 TSC2 USP4
Entrez ID 57521 6009
HPRD ID 06184 03188
Ensembl ID ENSG00000141564 ENSG00000106615
Uniprot IDs Q6DKI0 Q8N122 A0A090N900 Q15382
PDB IDs 5H64 6BCU 6BCX 6SB0 6SB2 6U62 1XTQ 1XTR 1XTS 3SEA 3T5G 5YXH 6BCU 6BSX 6BT0 7BTA 7BTC 7BTD
Enriched GO Terms of Interacting Partners?
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