RPTOR and MAPK3

Number of citations of the paper that reports this interaction (PubMedID 21071439)
103

Data Source:
BioGRID (enzymatic study, pull down)

		RPTOR	MAPK3
Description		regulatory associated protein of MTOR complex 1	mitogen-activated protein kinase 3
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Cytoplasmic Stress Granule Dendrite TORC1 Complex Neuronal Cell Body	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrion Early Endosome Late Endosome Endoplasmic Reticulum Lumen Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Caveola Focal Adhesion Pseudopodium Protein-containing Complex
	Molecular Function	RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding TFIIIC-class Transcription Factor Complex Binding Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Kinase Activator Activity Protein-macromolecule Adaptor Activity Protein-containing Complex Binding 14-3-3 Protein Binding	Phosphotyrosine Residue Binding Protein Serine/threonine Kinase Activity MAP Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Phosphatase Binding Identical Protein Binding Scaffold Protein Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Cell Growth Positive Regulation Of Endothelial Cell Proliferation Regulation Of Cell Size Cellular Response To Starvation Response To Xenobiotic Stimulus Regulation Of Autophagy Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Activation Of Protein Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Social Behavior TORC1 Signaling Negative Regulation Of Catalytic Activity Positive Regulation Of Transcription By RNA Polymerase III Cellular Response To Amino Acid Stimulus Cellular Response To Leucine Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	MAPK Cascade Positive Regulation Of Protein Phosphorylation Transcription, DNA-templated Protein Phosphorylation Apoptotic Process DNA Damage Induced Protein Phosphorylation Cell Cycle Cell Surface Receptor Signaling Pathway Aging Response To Toxic Substance Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Chemotaxis Phosphorylation Peptidyl-serine Phosphorylation Sensory Perception Of Pain Arachidonic Acid Metabolic Process Regulation Of Ossification BMP Signaling Pathway Regulation Of Cellular PH Thyroid Gland Development Positive Regulation Of Cyclase Activity Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Histone Phosphorylation Cellular Response To Amino Acid Starvation Cellular Response To Reactive Oxygen Species Positive Regulation Of Histone Acetylation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Outer Ear Morphogenesis Response To Exogenous DsRNA Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Decidualization Thymus Development Regulation Of DNA-binding Transcription Factor Activity Cartilage Development Stress-activated MAPK Cascade Regulation Of Cytoskeleton Organization Positive Regulation Of Telomerase Activity Bergmann Glial Cell Differentiation Face Development Lung Morphogenesis Trachea Formation Cardiac Neural Crest Cell Development Involved In Heart Development Protein-containing Complex Assembly ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Interleukin-1-mediated Signaling Pathway Response To Epidermal Growth Factor Cellular Response To Mechanical Stimulus Cellular Response To Cadmium Ion Cellular Response To Tumor Necrosis Factor Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Positive Regulation Of Macrophage Proliferation Cellular Response To Dopamine Positive Regulation Of Telomere Capping Positive Regulation Of Xenophagy Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Apolipoprotein Binding
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	MAPK3 (ERK1) activation RAF-independent MAPK1/3 activation ISG15 antiviral mechanism Spry regulation of FGF signaling Frs2-mediated activation ERK/MAPK targets ERK/MAPK targets ERKs are inactivated Regulation of actin dynamics for phagocytic cup formation Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Oncogene Induced Senescence FCERI mediated MAPK activation Regulation of HSF1-mediated heat shock response NCAM signaling for neurite out-growth RSK activation Signal transduction by L1 Activation of the AP-1 family of transcription factors Thrombin signalling through proteinase activated receptors (PARs) Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate NADPH Oxidases RAF/MAP kinase cascade MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RNA Polymerase I Promoter Opening Signal attenuation Advanced glycosylation endproduct receptor signaling Gastrin-CREB signalling pathway via PKC and MAPK ESR-mediated signaling RUNX2 regulates osteoblast differentiation Regulation of PTEN gene transcription Regulation of the apoptosome activity Estrogen-dependent nuclear events downstream of ESR-membrane signaling Suppression of apoptosis Signaling downstream of RAS mutants Signaling by MAP2K mutants Signaling by RAF1 mutants FCGR3A-mediated phagocytosis Nuclear events stimulated by ALK signaling in cancer Growth hormone receptor signaling
Drugs			Sulindac Acetylsalicylic acid Minocycline Arsenic trioxide Purvalanol 5-iodotubercidin Seliciclib Cholecystokinin Ulixertinib
Diseases
GWAS		Adult body size ( 32376654) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Body mass index ( 28892062 25673413) Body size at age 10 ( 32376654) Hypertension ( 30487518) Mean arterial pressure ( 30487518) NASH resolution in nonalcoholic steatohepatitis ( 31832568) Nicotine dependence symptom count ( 25555482) Obesity ( 23563607) Pulse pressure ( 29403010 30487518) Systolic blood pressure ( 30487518)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Childhood body mass index ( 33045005) Hodgkin's lymphoma ( 30194254) Multiple sclerosis ( 31604244 24076602) Pubertal anthropometrics ( 23449627) Schizophrenia ( 28991256 25056061 29483656) Tonsillectomy ( 27182965 28928442) Waist circumference ( 28552196) Weight ( 28552196)
Interacting Genes		30 interacting genes: BAHCC1 CBX8 CCDC40 CILK1 DCXR DUXAP9 EIF4EBP1 EIF4EBP2 IRS1 IRS2 LINC00839 MAPK1 MAPK3 MARK4 MLST8 MTOR NRBF2 PLD2 PRKAA1 PRKAA2 RAP1B RHEB RNF213 RPS6KA1 RPS6KB1 RRAGB TNRC6C USP36 WDR45B WIPI2	187 interacting genes: AKR1C1 AMOT ARRB1 ATP1A1 AURKA BCL2 BCL3 BRAF BTBD10 BUB1 C1QBP CASP8 CASP9 CAV1 CCDC6 CDC23 CDC25C CDC45 CDH1 CDKN2A CEBPB CPXM1 CREBBP CREM CRP CTNND1 CUEDC2 DAPK1 DCC DCP1A DCP2 DLC1 DUSP1 DUSP10 DUSP3 DUSP4 DUSP5 DUSP6 DUSP9 EGFR ELK1 ELK4 EPOR ESR1 ETS1 ETV1 FBXW7 FCGR2B FKBP2 FOS FOXP2 FRS2 GAB1 GAB2 GATA1 GATA4 GJA1 GMFB GRK2 GTF2I HDAC4 HDAC6 HIF1A HMMR HNF4A HSF1 HSF4 HSPB8 HTRA2 ID2 IER3 INSR IRS1 ITGAV ITGB3 JUN JUND KRT8 KSR2 L3MBTL3 LAMTOR3 LCK LIPE LRPAP1 LRRC4 LYN MAFG MAGEA11 MAGED1 MAP2K1 MAP2K2 MAP2K3 MAP3K14 MAPK14 MAPK8 MAPKAPK2 MAPT MBP MED1 METAP2 MKNK1 MYC MYLK MYOG NAB2 NCKIPSD NGFR NRAS NTRK1 NTRK3 NUP153 NUP58 PAK2 PDE6G PDGFRL PEA15 PFKM PLAT PLCB1 PPARA PPP1CA PPP2CA PRKCD PRKCE PRKCZ PTPN11 PTPN5 PTPN7 PTPRE PTPRR PXN RAB4A RAF1 RALGDS RB1 RCAN1 RET RNF114 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KB1 RPTOR RXRA SCAND1 SCRIB SMAD2 SNCG SORBS3 SOS1 SOX2 SP1 SPIB SRC SREBF1 SREBF2 STAR STAT3 STAT5A STK11 STMN1 STMN2 STUB1 SULT4A1 SYK SYN1 SYNE2 TAL1 TAL2 TCF3 TGIF1 TH TNFSF11 TOP2B TP53 TRIM54 TSC2 TTYH3 UBE4B UBTF USP21 VDR VPS52 ZC3HC1 ZNF219 ZNF7
Entrez ID		57521	5595
HPRD ID		06184	03479
Ensembl ID		ENSG00000141564	ENSG00000102882
Uniprot IDs		Q6DKI0 Q8N122	L7RXH5 P27361 Q9BWJ1
PDB IDs		5H64 6BCU 6BCX 6SB0 6SB2 6U62	2ZOQ 4QTB 6GES
Enriched GO Terms of Interacting Partners?
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