CXCL10 and PPBP

Number of citations of the paper that reports this interaction (PubMedID 28381538)
37

Data Source:
BioGRID (pull down)

		CXCL10	PPBP
Description		C-X-C motif chemokine ligand 10	pro-platelet basic protein
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Tertiary Granule Lumen
	Molecular Function	Signaling Receptor Binding Protein Binding Chemokine Activity Heparin Binding CAMP-dependent Protein Kinase Regulator Activity Chemoattractant Activity CXCR Chemokine Receptor Binding CXCR3 Chemokine Receptor Binding	Glucose Transmembrane Transporter Activity Protein Binding Chemokine Activity Growth Factor Activity CXCR Chemokine Receptor Binding
	Biological Process	Chemotaxis Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Muscle Organ Development Blood Circulation Positive Regulation Of Cell Population Proliferation Response To Cold Response To Gamma Radiation T Cell Chemotaxis Regulation Of T Cell Chemotaxis Response To Auditory Stimulus Negative Regulation Of Angiogenesis Neutrophil Chemotaxis Response To Vitamin D Cellular Response To Heat Endothelial Cell Activation Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Negative Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Catalytic Activity Positive Chemotaxis Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotaxis Cellular Response To Virus Antiviral Innate Immune Response Regulation Of Endothelial Tube Morphogenesis Negative Regulation Of Myoblast Fusion Positive Regulation Of T Cell Migration	Inflammatory Response Neutrophil Chemotaxis Defense Response To Bacterium Positive Regulation Of Cell Division Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Glucose Transmembrane Transport
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	Platelet degranulation Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation
Drugs		N-Methylleucine Eldelumab Clove oil	Ethanesulfonic acid Copper
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) C-X-C motif chemokine 10 levels ( 25147954) Hippocampal volume ( 29274321) Interferon gamma-induced protein 10 levels ( 27989323 31217265) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)	Metabolite levels ( 22916037)
Interacting Genes		22 interacting genes: CCL11 CCL13 CCL21 CCL26 CCL28 CCL5 CCL8 CCR3 CXCL11 CXCL12 CXCL14 CXCL17 CXCL6 CXCL9 CXCR3 DPP4 IGFBP7 PF4 PF4V1 PPBP VCAN XCL1	32 interacting genes: CCL13 CCL21 CCL26 CCL28 CCL5 CCL8 CELF1 CMTM6 COPG1 COPS7A COX17 CTSG CXCL10 CXCL11 CXCL12 CXCL14 CXCL6 CXCL9 CXCR1 CXCR2 DMWD EFNA1 MAPK6 MOB3B NDUFB11 NR4A1 PLEKHJ1 PMAIP1 RAB10 RPS27 SCFD1 STRN4
Entrez ID		3627	5473
HPRD ID		00930	07171
Ensembl ID		ENSG00000169245	ENSG00000163736
Uniprot IDs		P02778	P02775
PDB IDs		1LV9 1O7Y 1O7Z 1O80	1F9P 1NAP 1TVX
Enriched GO Terms of Interacting Partners?
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