PPBP and CXCL6

Number of citations of the paper that reports this interaction (PubMedID 28381538)
37

Data Source:
BioGRID (pull down)

		PPBP	CXCL6
Description		pro-platelet basic protein	C-X-C motif chemokine ligand 6
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Tertiary Granule Lumen	Extracellular Region Extracellular Space
	Molecular Function	Glucose Transmembrane Transporter Activity Protein Binding Chemokine Activity Growth Factor Activity CXCR Chemokine Receptor Binding	Protein Binding Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding
	Biological Process	Inflammatory Response Neutrophil Chemotaxis Defense Response To Bacterium Positive Regulation Of Cell Division Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Glucose Transmembrane Transport	Leukocyte Homeostasis Chemotaxis Inflammatory Response Signal Transduction Cell-cell Signaling Neutrophil Chemotaxis Regulation Of Chemokine Production Neutrophil Activation Defense Response To Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Cellular Response To Lipopolysaccharide
Pathways		Platelet degranulation Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		Ethanesulfonic acid Copper
Diseases
GWAS		Metabolite levels ( 22916037)	Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494) Blood protein levels ( 28240269) Blood protein levels in cardiovascular risk ( 28369058) Eosinophil percentage of granulocytes ( 27863252) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Neutrophil count ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)
Interacting Genes		32 interacting genes: CCL13 CCL21 CCL26 CCL28 CCL5 CCL8 CELF1 CMTM6 COPG1 COPS7A COX17 CTSG CXCL10 CXCL11 CXCL12 CXCL14 CXCL6 CXCL9 CXCR1 CXCR2 DMWD EFNA1 MAPK6 MOB3B NDUFB11 NR4A1 PLEKHJ1 PMAIP1 RAB10 RPS27 SCFD1 STRN4	14 interacting genes: CCL11 CCL5 CCL7 CCL8 CXCL1 CXCL10 CXCL12 CXCL2 CXCL3 CXCR1 CXCR2 MMP9 PF4 PPBP
Entrez ID		5473	6372
HPRD ID		07171	00735
Ensembl ID		ENSG00000163736	ENSG00000124875
Uniprot IDs		P02775	P80162
PDB IDs		1F9P 1NAP 1TVX
Enriched GO Terms of Interacting Partners?
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