PPBP and CCL8

Number of citations of the paper that reports this interaction (PubMedID 28381538)
37

Data Source:
BioGRID (pull down)

		PPBP	CCL8
Description		pro-platelet basic protein	C-C motif chemokine ligand 8
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Tertiary Granule Lumen	Extracellular Space
	Molecular Function	Glucose Transmembrane Transporter Activity Protein Binding Chemokine Activity Growth Factor Activity CXCR Chemokine Receptor Binding	Protein Kinase Activity Protein Binding Chemokine Activity Heparin Binding Phospholipase Activator Activity CCR Chemokine Receptor Binding
	Biological Process	Inflammatory Response Neutrophil Chemotaxis Defense Response To Bacterium Positive Regulation Of Cell Division Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Glucose Transmembrane Transport	Monocyte Chemotaxis Positive Regulation Of Leukocyte Migration Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Negative Regulation By Host Of Viral Genome Replication Eosinophil Chemotaxis Lymphocyte Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Leukocyte Proliferation Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor
Pathways		Platelet degranulation Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation
Drugs		Ethanesulfonic acid Copper	Pidolic acid
Diseases
GWAS		Metabolite levels ( 22916037)	Blood protein levels ( 30072576 29875488 28240269) Crohn's disease ( 22412388) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		32 interacting genes: CCL13 CCL21 CCL26 CCL28 CCL5 CCL8 CELF1 CMTM6 COPG1 COPS7A COX17 CTSG CXCL10 CXCL11 CXCL12 CXCL14 CXCL6 CXCL9 CXCR1 CXCR2 DMWD EFNA1 MAPK6 MOB3B NDUFB11 NR4A1 PLEKHJ1 PMAIP1 RAB10 RPS27 SCFD1 STRN4	21 interacting genes: ACKR1 ACKR2 ACKR4 CCL11 CCL13 CCL2 CCL26 CCR1 CCR3 CCR5 CXCL10 CXCL11 CXCL17 CXCL2 CXCL6 CXCL8 MMP3 PPBP SDF2 VCAN XCL2
Entrez ID		5473	6355
HPRD ID		07171	03791
Ensembl ID		ENSG00000163736	ENSG00000108700
Uniprot IDs		P02775	P80075
PDB IDs		1F9P 1NAP 1TVX	1ESR
Enriched GO Terms of Interacting Partners?
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