PPBP and CMTM6

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		PPBP	CMTM6
Description		pro-platelet basic protein	CKLF like MARVEL transmembrane domain containing 6
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Tertiary Granule Lumen	Plasma Membrane Membrane Integral Component Of Membrane Early Endosome Membrane Azurophil Granule Membrane Specific Granule Membrane Intracellular Membrane-bounded Organelle Recycling Endosome Membrane
	Molecular Function	Glucose Transmembrane Transporter Activity Protein Binding Chemokine Activity Growth Factor Activity CXCR Chemokine Receptor Binding	Protein Binding
	Biological Process	Inflammatory Response Neutrophil Chemotaxis Defense Response To Bacterium Positive Regulation Of Cell Division Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Glucose Transmembrane Transport	Protein Transport Regulation Of Protein Stability Endocytic Recycling
Pathways		Platelet degranulation Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation	Neutrophil degranulation
Drugs		Ethanesulfonic acid Copper
Diseases
GWAS		Metabolite levels ( 22916037)	Apolipoprotein B levels ( 32203549) Beta blocker survival benefit in heart failure with reduced ejection fraction (time to all cause mortality x beta blocker interaction) ( 33012170) Cholesterol, total ( 24097068) LDL cholesterol ( 24097068 30275531) LDL cholesterol levels ( 32203549 28334899) Low density lipoprotein cholesterol levels ( 32154731) Total cholesterol levels ( 28334899 30275531)
Interacting Genes		32 interacting genes: CCL13 CCL21 CCL26 CCL28 CCL5 CCL8 CELF1 CMTM6 COPG1 COPS7A COX17 CTSG CXCL10 CXCL11 CXCL12 CXCL14 CXCL6 CXCL9 CXCR1 CXCR2 DMWD EFNA1 MAPK6 MOB3B NDUFB11 NR4A1 PLEKHJ1 PMAIP1 RAB10 RPS27 SCFD1 STRN4	24 interacting genes: APOA5 ATP13A2 BPIFA2 CD160 CD40 CIAO2A COQ8A DNMT3B DUSP10 DYNC1LI1 ECPAS EHHADH FAM9B MIEF1 PPBP RBFA RBMX RUSC1 SNRPB2 SPG21 SUMO2 TCEA2 TMED8 XRCC6
Entrez ID		5473	54918
HPRD ID		07171	06987
Ensembl ID		ENSG00000163736	ENSG00000091317
Uniprot IDs		P02775	Q9NX76
PDB IDs		1F9P 1NAP 1TVX
Enriched GO Terms of Interacting Partners?
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