HLA-DMA and B3GAT1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		HLA-DMA	B3GAT1
Description		major histocompatibility complex, class II, DM alpha	beta-1,3-glucuronyltransferase 1
Image
GO Annotations	Cellular Component	Lysosomal Membrane Cell Surface Membrane Integral Component Of Membrane Late Endosome Membrane MHC Class II Protein Complex Intracellular Membrane-bounded Organelle	Golgi Membrane Extracellular Region Endoplasmic Reticulum Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding MHC Class II Protein Complex Binding	Protein Binding UDP-galactose:beta-N-acetylglucosamine Beta-1,3-galactosyltransferase Activity Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase Activity Metal Ion Binding
	Biological Process	Adaptive Immune Response Immunoglobulin Production Involved In Immunoglobulin-mediated Immune Response Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of T Cell Activation	Carbohydrate Metabolic Process Protein Glycosylation Chondroitin Sulfate Proteoglycan Biosynthetic Process Cellular Response To Hypoxia
Pathways			A tetrasaccharide linker sequence is required for GAG synthesis
Drugs			D-tartaric acid Uridine-5'-Diphosphate
Diseases
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848)	Liver enzyme levels (alkaline phosphatase) ( 33972514) N-glycan levels ( 21908519) Neonatal white matter microstructure ( 33009551) Prostate cancer ( 29892016) Schizophrenia ( 33169155) Serum alkaline phosphatase levels ( 33547301) Verbal declarative memory ( 25648963)
Interacting Genes		8 interacting genes: B3GAT1 CD74 CD82 HLA-DMB HLA-DOA HLA-DRA HLA-DRB1 U2AF2	3 interacting genes: CMTM7 HLA-DMA SH3GL1
Entrez ID		3108	27087
HPRD ID		00830	06969
Ensembl ID		ENSG00000204257	ENSG00000109956
Uniprot IDs		Q31604 Q6ICR9	Q9P2W7
PDB IDs		4I0P	1V82 1V83 1V84
Enriched GO Terms of Interacting Partners?
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