B3GAT1 and HLA-DMA

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		B3GAT1	HLA-DMA
Description		beta-1,3-glucuronyltransferase 1	major histocompatibility complex, class II, DM alpha
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Endoplasmic Reticulum Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Lysosomal Membrane Cell Surface Membrane Integral Component Of Membrane Late Endosome Membrane MHC Class II Protein Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding UDP-galactose:beta-N-acetylglucosamine Beta-1,3-galactosyltransferase Activity Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase Activity Metal Ion Binding	Protein Binding MHC Class II Protein Complex Binding
	Biological Process	Carbohydrate Metabolic Process Protein Glycosylation Chondroitin Sulfate Proteoglycan Biosynthetic Process Cellular Response To Hypoxia	Adaptive Immune Response Immunoglobulin Production Involved In Immunoglobulin-mediated Immune Response Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of T Cell Activation
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis
Drugs		D-tartaric acid Uridine-5'-Diphosphate
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514) N-glycan levels ( 21908519) Neonatal white matter microstructure ( 33009551) Prostate cancer ( 29892016) Schizophrenia ( 33169155) Serum alkaline phosphatase levels ( 33547301) Verbal declarative memory ( 25648963)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848)
Interacting Genes		3 interacting genes: CMTM7 HLA-DMA SH3GL1	8 interacting genes: B3GAT1 CD74 CD82 HLA-DMB HLA-DOA HLA-DRA HLA-DRB1 U2AF2
Entrez ID		27087	3108
HPRD ID		06969	00830
Ensembl ID		ENSG00000109956	ENSG00000204257
Uniprot IDs		Q9P2W7	Q31604 Q6ICR9
PDB IDs		1V82 1V83 1V84	4I0P
Enriched GO Terms of Interacting Partners?
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