ANGPTL3 and ITGA5

Number of citations of the paper that reports this interaction (PubMedID 11877390)
76

Data Source:
HPRD (in vitro)

		ANGPTL3	ITGA5
Description		angiopoietin like 3	integrin subunit alpha 5
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Golgi Apparatus Cell Surface Lamellipodium Collagen-containing Extracellular Matrix	Ruffle Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex Cell Surface Ruffle Membrane Integrin Alpha5-beta1 Complex Alphav-beta3 Integrin-vitronectin Complex
	Molecular Function	Enzyme Inhibitor Activity Phospholipase Inhibitor Activity Signaling Receptor Binding Integrin Binding Growth Factor Activity Heparin Binding	Virus Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Metal Ion Binding
	Biological Process	Angiogenesis Glycerol Metabolic Process Fatty Acid Metabolic Process Phospholipid Metabolic Process Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Cholesterol Metabolic Process Phospholipid Catabolic Process Response To Hormone Negative Regulation Of Phospholipase Activity Lipid Storage Positive Regulation Of Cell Migration Cholesterol Homeostasis Positive Regulation Of Angiogenesis Artery Morphogenesis Positive Regulation Of Lipid Catabolic Process Negative Regulation Of Lipoprotein Lipase Activity Lipid Homeostasis Acylglycerol Homeostasis Phospholipid Homeostasis Triglyceride Homeostasis	Angiogenesis Cell Adhesion Integrin-mediated Signaling Pathway CD40 Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Viral Entry Into Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Anoikis
Pathways		Assembly of active LPL and LIPC lipase complexes NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions Signal transduction by L1 RUNX2 regulates genes involved in cell migration
Drugs			Resveratrol
Diseases
GWAS		Blood metabolite levels ( 24816252) Blood protein levels ( 30072576) Cholesterol, total ( 24097068 25961943 20686565 26582766) Crohn's disease ( 28067908) LDL cholesterol ( 24097068 25961943 20686565) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219 19936222) Metabolite levels ( 22916037) Metabolite levels (lipid measures) ( 27005778) Regular attendance at a gym or sports club ( 29970889) Total cholesterol levels ( 28334899) Total triglycerides levels ( 26690388) Triglyceride levels ( 28334899 29615537) Triglycerides ( 24097068 18193043 18193044 20864672 19060906 20139978 25961943 20686565 26582766)	Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		4 interacting genes: ITGA5 ITGAV ITGB3 UBC	33 interacting genes: ANGPT1 ANGPT2 ANGPTL3 ARHGAP5 AUP1 CD9 CHMP2A CLK1 COL18A1 COL1A1 EGFR ERBB2 FGFR2 FLT4 FN1 GIPC1 GPR182 GRK6 ITGB1 ITGB3 ITGB5 L1CAM LGALS3BP NISCH PECAM1 RABIF SHARPIN SPP1 STAMBP THAP1 TNC UBAP1 VCL
Entrez ID		27329	3678
HPRD ID		10381	00627
Ensembl ID		ENSG00000132855	ENSG00000161638
Uniprot IDs		Q9Y5C1	B2R627 P08648
PDB IDs		6EUA	3VI3 3VI4 4WJK 4WK0 4WK2 4WK4
Enriched GO Terms of Interacting Partners?
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