ITGA5 and ANGPT1

Number of citations of the paper that reports this interaction (PubMedID 15781448)
15

Data Source:
HPRD (in vitro)

		ITGA5	ANGPT1
Description		integrin subunit alpha 5	angiopoietin 1
Image
GO Annotations	Cellular Component	Ruffle Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex Cell Surface Ruffle Membrane Integrin Alpha5-beta1 Complex Alphav-beta3 Integrin-vitronectin Complex	Extracellular Region Extracellular Space Plasma Membrane Microvillus Membrane Raft Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Virus Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Metal Ion Binding	Signaling Receptor Binding Receptor Tyrosine Kinase Binding
	Biological Process	Angiogenesis Cell Adhesion Integrin-mediated Signaling Pathway CD40 Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Viral Entry Into Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Anoikis	Angiogenesis In Utero Embryonic Development Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Positive Regulation Of Receptor Internalization Negative Regulation Of Cytokine Production Involved In Immune Response Negative Regulation Of Cell Adhesion Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Skeletal Muscle Satellite Cell Proliferation Hemopoiesis Cell Differentiation Heparin Biosynthetic Process Positive Regulation Of Protein Ubiquitination Cell-substrate Adhesion Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Peptidyl-serine Phosphorylation Protein Localization To Cell Surface Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Negative Regulation Of Vascular Permeability Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Binding Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Adhesion Tie Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Glomerulus Vasculature Development Positive Regulation Of Blood-brain Barrier Permeability Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway
Pathways		Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions Signal transduction by L1 RUNX2 regulates genes involved in cell migration	Tie2 Signaling Tie2 Signaling RAF/MAP kinase cascade
Drugs		Resveratrol
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Blood protein levels ( 30072576) Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Corneal astigmatism ( 29422769) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Face memory ( 31596458) Fractional exhaled nitric oxide (childhood) ( 24315451) Glaucoma ( 31959993 30054594) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (primary open-angle) ( 33627673 29891935) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Intraocular pressure ( 29617998 29785010 31959993 30054594 29235454) Male-pattern baldness ( 28196072) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (antiglaucoma preparations and miotics) ( 31015401) Periodontitis (stage III/IV grade C) ( 33745150) Periventricular white matter hyperintensities ( 32517579) Platelet distribution width ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		33 interacting genes: ANGPT1 ANGPT2 ANGPTL3 ARHGAP5 AUP1 CD9 CHMP2A CLK1 COL18A1 COL1A1 EGFR ERBB2 FGFR2 FLT4 FN1 GIPC1 GPR182 GRK6 ITGB1 ITGB3 ITGB5 L1CAM LGALS3BP NISCH PECAM1 RABIF SHARPIN SPP1 STAMBP THAP1 TNC UBAP1 VCL	4 interacting genes: ANGPT2 ITGA5 TEK TIE1
Entrez ID		3678	284
HPRD ID		00627	03392
Ensembl ID		ENSG00000161638	ENSG00000154188
Uniprot IDs		B2R627 P08648	B4DTQ9 Q15389
PDB IDs		3VI3 3VI4 4WJK 4WK0 4WK2 4WK4	4EPU 4JYO 4K0V
Enriched GO Terms of Interacting Partners?
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