ITGA5 and PECAM1

Number of citations of the paper that reports this interaction (PubMedID 10982404)
21

Data Source:
HPRD (in vivo)

		ITGA5	PECAM1
Description		integrin subunit alpha 5	platelet and endothelial cell adhesion molecule 1
Image
GO Annotations	Cellular Component	Ruffle Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex Cell Surface Ruffle Membrane Integrin Alpha5-beta1 Complex Alphav-beta3 Integrin-vitronectin Complex	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Secretory Granule Membrane Platelet Alpha Granule Membrane Protein-containing Complex Membrane Raft Extracellular Exosome
	Molecular Function	Virus Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Metal Ion Binding	Transmembrane Signaling Receptor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Angiogenesis Cell Adhesion Integrin-mediated Signaling Pathway CD40 Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Viral Entry Into Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Anoikis	Positive Regulation Of Protein Phosphorylation Phagocytosis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Cell-cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Cell Recognition Positive Regulation Of Cell Migration Maintenance Of Blood-brain Barrier Monocyte Extravasation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Diapedesis Establishment Of Endothelial Barrier Bicellular Tight Junction Assembly Glomerular Endothelium Development Neutrophil Extravasation Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Protein Localization To Cell-cell Junction
Pathways		Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions Signal transduction by L1 RUNX2 regulates genes involved in cell migration	Platelet degranulation Cell surface interactions at the vascular wall PECAM1 interactions Integrin cell surface interactions Platelet sensitization by LDL Neutrophil degranulation
Drugs		Resveratrol
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Coronary artery disease ( 32469254 29212778 33020668) Myocardial infarction ( 33532862) Pulse pressure ( 27841878 30578418) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189) Systolic blood pressure ( 27841878)
Interacting Genes		33 interacting genes: ANGPT1 ANGPT2 ANGPTL3 ARHGAP5 AUP1 CD9 CHMP2A CLK1 COL18A1 COL1A1 EGFR ERBB2 FGFR2 FLT4 FN1 GIPC1 GPR182 GRK6 ITGB1 ITGB3 ITGB5 L1CAM LGALS3BP NISCH PECAM1 RABIF SHARPIN SPP1 STAMBP THAP1 TNC UBAP1 VCL	24 interacting genes: BRIP1 CD38 CSK CTNNB1 DSP EFNB2 FOXJ1 FYN HCK INPP5D ITGA5 ITGB3 JUP LCK LYN PIK3R1 PLCG1 PRKCE PRPF40A PTPN11 PTPN6 SRC XRCC6 YES1
Entrez ID		3678	5175
HPRD ID		00627	01425
Ensembl ID		ENSG00000161638	ENSG00000261371
Uniprot IDs		B2R627 P08648	P16284
PDB IDs		3VI3 3VI4 4WJK 4WK0 4WK2 4WK4	2KY5 5C14 5GNI
Enriched GO Terms of Interacting Partners?
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