GCSH and RHBDD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GCSH	RHBDD2
Description		glycine cleavage system protein H	rhomboid domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Glycine Cleavage Complex	Golgi Membrane Hrd1p Ubiquitin Ligase ERAD-L Complex Nucleoplasm Golgi Apparatus Integral Component Of Endoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Aminomethyltransferase Activity Protein Binding	Serine-type Endopeptidase Activity Misfolded Protein Binding Ubiquitin-specific Protease Binding
	Biological Process	Glycine Catabolic Process Protein Lipoylation Glycine Decarboxylation Via Glycine Cleavage System	Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response
Pathways		Glyoxylate metabolism and glycine degradation Glycine degradation
Drugs		6-(Hydroxyethyldithio)-8-(Aminomethylthio)Octanoic Acid Dihydrolipoic Acid
Diseases
GWAS		Glycine levels ( 31070104 30837465) Metabolite levels (small molecules and protein measures) ( 27005778) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		10 interacting genes: CIDEB ING5 MAGEA11 MAGEA6 MED11 MIS18A NMI RHBDD2 SFI1 ZBTB16	58 interacting genes: ABHD16A ACSF2 ADORA2A BCL2L1 BCL2L2 CCR9 CHRM4 CIAO2A CIDEB COL8A1 COMT DIABLO DRD2 DYNC1H1 ERBB2 FKBP8 FMO4 GAL3ST3 GCSH GDF5-AS1 H2BC3 H4C7 IFI27L1 IL32 LETMD1 LIG4 MAOB MFSD14C MICOS13 MIEF2 MLX MMRN2 MPC2 MRM1 MRPL35 MTERF3 MYG1 NAALAD2 NCBP2AS2 NFU1 NRM PBX3 PTAFR ROMO1 RSAD2 SCGB3A1 SDHD SLC25A2 SLC25A3 SNPH SYT16 TEX44 THBD TIMM17B TPRG1 TSR1 TUFM USP30
Entrez ID		2653	57414
HPRD ID		01998	11492
Ensembl ID		ENSG00000140905	ENSG00000005486
Uniprot IDs		P23434	Q6NTF9
PDB IDs
Enriched GO Terms of Interacting Partners?
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