TXN2 and PPP1R16B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TXN2	PPP1R16B
Description		thioredoxin 2	protein phosphatase 1 regulatory subunit 16B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleolus Mitochondrion Mitochondrial Matrix Dendrite Neuronal Cell Body	Nucleus Plasma Membrane Nuclear Speck Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Peptide-methionine (S)-S-oxide Reductase Activity Protein-disulfide Reductase Activity Peptide-methionine (R)-S-oxide Reductase Activity Protein-containing Complex Binding	Protein Binding Protein Phosphatase 1 Binding Myosin Phosphatase Regulator Activity Protein Phosphatase Regulator Activity
	Biological Process	Response To Hypoxia Glycerol Ether Metabolic Process Response To Oxidative Stress Response To Xenobiotic Stimulus Response To Hormone Response To Glucose Response To Organic Cyclic Compound Cellular Response To Nutrient Levels Cell Redox Homeostasis Response To Axon Injury	Positive Regulation Of Endothelial Cell Proliferation Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Protein Dephosphorylation Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Protein Dephosphorylation Regulation Of Catalytic Activity Regulation Of Filopodium Assembly Establishment Of Endothelial Barrier Negative Regulation Of Peptidyl-serine Dephosphorylation Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Sprouting Angiogenesis
Pathways		Degradation of cysteine and homocysteine Detoxification of Reactive Oxygen Species
Drugs
Diseases
GWAS			Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis ( 28714907) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diverticular disease ( 30177863) Huntington's disease progression ( 28642124) Mean corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Schizophrenia ( 25056061 29483656 30285260)
Interacting Genes		80 interacting genes: ABI3 AGTRAP ALDOB ANKRD36B AP2B1 BCAS2 BHLHB9 C11orf49 CCDC197 CDCA4 CEP70 CGGBP1 CHMP1A CIB4 CRACR2B DCTD DDIT3 ETHE1 FAM9B FHL5 FMNL2 GOLGA6L9 GPRASP2 GTPBP2 GUCD1 HAUS1 HAUS8 KAZN KRT18 KRT27 KRT40 LCN2 MAGEA11 MAGEA4 MAGEB2 MAPRE2 MAPRE3 MDFI MEOX2 MIPOL1 MLH1 MRFAP1 MRFAP1L1 MTUS2 MYL9 NUTM1 ODAD1 PEX19 POMC PPCDC PPP1R16B PSME3 RABAC1 RABGEF1 RBM45 REEP6 RPIA SAT1 SCYL3 SHARPIN SPTA1 SSNA1 STN1 STUB1 SUN2 SYCE1 TFIP11 THAP1 TIFA TMOD4 TRIM21 TRIP6 TTC32 UCHL5 UQCC2 VIM VPS52 ZBTB14 ZMYND12 ZSCAN32	45 interacting genes: ATPAF2 CDCA7L CDK5RAP1 CEP55 CEP70 CRX DVL2 DVL3 FAM83A FAM83D FARS2 FLYWCH1 GATA1 GFAP GOLGA2 HAPLN2 IKZF3 KCTD9 MAGOH MCEE MISP MYL9 NEFL NFX1 PATZ1 PHC2 PLEKHN1 PPP1CA PPP1CB RBPMS RFC5 SCNM1 SF3B4 SHC3 SSR4 TACO1 TADA2A TASOR2 TFIP11 TLE5 TTI1 TUFM TXN2 ZNF410 ZNF564
Entrez ID		25828	26051
HPRD ID		07161	15168
Ensembl ID		ENSG00000100348	ENSG00000101445
Uniprot IDs		Q99757	Q96T49
PDB IDs		1UVZ 1W4V 1W89
Enriched GO Terms of Interacting Partners?
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