JADE2 and RAPGEF6

		JADE2	RAPGEF6
Description		jade family PHD finger 2	Rap guanine nucleotide exchange factor 6
Image		No pdb structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleoplasm Extracellular Exosome	Centrosome Cytosol Plasma Membrane Apical Plasma Membrane Endocytic Vesicle
	Molecular Function	Protein Binding Transferase Activity Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP-dependent Protein Binding Small GTPase Binding Phosphatidic Acid Binding
	Biological Process	Protein Ubiquitination Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K12 Acetylation Histone H4-K16 Acetylation	Ras Protein Signal Transduction Microvillus Assembly Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier
Pathways		HATs acetylate histones
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first birth ( 34211149 27798627) Body mass index ( 28892062) Brain morphology (MOSTest) ( 32665545) Coffee consumption ( 31046077) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hand grip strength ( 29691431) Household income (MTAG) ( 31844048) Mental health study participation (completed survey) ( 31263887) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Platelet distribution width ( 27863252) Smoking cessation ( 33082346) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 28869590) White blood cell count ( 32888494)	Alzheimer's disease in APOE e4- carriers ( 25778476) Asthma ( 32296059) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diisocyanate-induced asthma ( 25918132) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Perceived unattractiveness to mosquitoes ( 28199695) Subcortical volume (MOSTest) ( 32665545) Subjective well-being ( 27089181) Ulcerative colitis ( 28067908)
Interacting Genes		27 interacting genes: C5orf15 CBX8 CDCA7L CSNK2A1 DDX46 FBXO7 FSTL4 GAS2L2 GORASP2 H3-4 ING4 IRAK1 KLK2 MEAF6 PACSIN1 RAPGEF6 SAR1B SASH1 SH2B2 SMAD5-AS1 TCF7 UQCRQ ZBTB3 ZBTB5 ZCCHC10 ZNF417 ZNF496	9 interacting genes: ABCA1 JADE2 LINC00839 MRAS NEDD4 PTPN13 RAP1A RAP2A YWHAG
Entrez ID		23338	51735
HPRD ID		15124	11483
Ensembl ID		ENSG00000043143	ENSG00000158987
Uniprot IDs		A0A0C4DFT8 B3KPL2 B4DFY8 G3XAA4 Q9NQC1	B2RTU6 Q8TEU7
PDB IDs			2D93 3LNY
Enriched GO Terms of Interacting Partners?
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