RAPGEF6

Description		Rap guanine nucleotide exchange factor 6
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GO Annotations	Cellular Component	Centrosome Cytosol Plasma Membrane Apical Plasma Membrane Endocytic Vesicle
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP-dependent Protein Binding Small GTPase Binding Phosphatidic Acid Binding
	Biological Process	Ras Protein Signal Transduction Microvillus Assembly Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier
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GWAS		Alzheimer's disease in APOE e4- carriers ( 25778476) Asthma ( 32296059) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diisocyanate-induced asthma ( 25918132) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Perceived unattractiveness to mosquitoes ( 28199695) Subcortical volume (MOSTest) ( 32665545) Subjective well-being ( 27089181) Ulcerative colitis ( 28067908)
Interacting Genes		9 interacting genes: ABCA1 JADE2 LINC00839 MRAS NEDD4 PTPN13 RAP1A RAP2A YWHAG
Entrez ID		51735
HPRD ID		11483
Ensembl ID		ENSG00000158987
Uniprot IDs		B2RTU6 Q8TEU7
PDB IDs		2D93 3LNY
Enriched GO Terms of Interacting Partners?
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