JADE2 and TCF7

		JADE2	TCF7
Description		jade family PHD finger 2	transcription factor 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleoplasm Extracellular Exosome	Nucleus Nucleoplasm Nuclear Body Beta-catenin-TCF Complex
	Molecular Function	Protein Binding Transferase Activity Metal Ion Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity Protein Binding Beta-catenin Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Ubiquitination Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K12 Acetylation Histone H4-K16 Acetylation	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Immune Response T Cell Receptor V(D)J Recombination Gamma-delta T Cell Differentiation Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Transcription, DNA-templated Canonical Wnt Signaling Pathway Cellular Response To Interleukin-4
Pathways		HATs acetylate histones	Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes Repression of WNT target genes RUNX3 regulates WNT signaling
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first birth ( 34211149 27798627) Body mass index ( 28892062) Brain morphology (MOSTest) ( 32665545) Coffee consumption ( 31046077) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hand grip strength ( 29691431) Household income (MTAG) ( 31844048) Mental health study participation (completed survey) ( 31263887) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Platelet distribution width ( 27863252) Smoking cessation ( 33082346) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 28869590) White blood cell count ( 32888494)	Autoimmune thyroid disease ( 32581359) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Menarche (age at onset) ( 25231870) Multiple sclerosis ( 31604244 24076602 21833088) Rheumatoid arthritis ( 32868391) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 33272962 26502338 28714469) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		27 interacting genes: C5orf15 CBX8 CDCA7L CSNK2A1 DDX46 FBXO7 FSTL4 GAS2L2 GORASP2 H3-4 ING4 IRAK1 KLK2 MEAF6 PACSIN1 RAPGEF6 SAR1B SASH1 SH2B2 SMAD5-AS1 TCF7 UQCRQ ZBTB3 ZBTB5 ZCCHC10 ZNF417 ZNF496	4 interacting genes: GOLGA3 JADE2 SS18L1 UCHL5
Entrez ID		23338	6932
HPRD ID		15124	01797
Ensembl ID		ENSG00000043143	ENSG00000081059
Uniprot IDs		A0A0C4DFT8 B3KPL2 B4DFY8 G3XAA4 Q9NQC1	B3KQ75 P36402
PDB IDs
Enriched GO Terms of Interacting Partners?
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