MAN2B2 and LIME1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MAN2B2	LIME1
Description		mannosidase alpha class 2B member 2	Lck interacting transmembrane adaptor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Vacuolar Membrane Lysosomal Lumen Extracellular Exosome	Extracellular Space Integral Component Of Membrane B Cell Receptor Complex
	Molecular Function	Alpha-mannosidase Activity Protein Binding Carbohydrate Binding Metal Ion Binding	Protein Binding Protein Kinase Binding
	Biological Process	Mannose Metabolic Process	Adaptive Immune Response Regulation Of Transcription By RNA Polymerase II Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of MAP Kinase Activity T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of NIK/NF-kappaB Signaling
Pathways		Lysosomal oligosaccharide catabolism
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Metabolite levels ( 23823483)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Apolipoprotein A1 levels ( 33730874) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Bell's palsy ( 33602968) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31015462) Inflammatory bowel disease ( 28067908 23128233) Meat-related diet ( 32066663) Prostate cancer ( 23535732) Refractive error ( 32231278) Ulcerative colitis ( 28067908)
Interacting Genes		9 interacting genes: APPBP2 CISD2 CPLX4 CREB3L1 FKBP7 GPX8 KCNK5 KRTAP3-2 LIME1	46 interacting genes: AGR3 AIG1 AQP1 ARFGAP3 BNIP2 C14orf180 CALN1 CIAO2A CLN6 EMD FRMD8 GAD2 GOSR2 GRB2 LCK LHFPL5 LPAR3 LYN MAN2B2 MEST MIEF2 NDRG4 NINJ1 PBX3 PKMYT1 PLCG2 PNPO PTPN9 RTP2 SEC22C SLC41A2 SNAP47 SNX1 STX6 STX7 TBRG4 TMBIM6 TMEM143 TMEM243 TMEM74 TMEM86B TMEM97 TRAF3IP3 UNC93B1 UPK2 ZFPL1
Entrez ID		23324	54923
HPRD ID		14355	07904
Ensembl ID		ENSG00000013288	ENSG00000203896
Uniprot IDs		B7Z754 E9PCD7 Q9Y2E5	A0A087WT39 Q9H400
PDB IDs
Enriched GO Terms of Interacting Partners?
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