FCHO1 and GDF15

		FCHO1	GDF15
Description		FCH and mu domain containing endocytic adaptor 1	growth differentiation factor 15
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Clathrin-coated Vesicle	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Apparatus Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding AP-2 Adaptor Complex Binding	Cytokine Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity BMP Receptor Binding
	Biological Process	Clathrin Coat Assembly Clathrin-dependent Endocytosis	Reduction Of Food Intake In Response To Dietary Excess Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Myoblast Fusion
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Basophil count ( 32888494) Coronary artery disease ( 29212778) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Monocyte percentage of white cells ( 32888494) Myocardial infarction ( 33532862)	Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Coffee consumption ( 31046077) Growth differentiation factor-15 levels ( 29628937) Hyperemesis gravidarum ( 29563502) Liver enzyme levels (alkaline phosphatase) ( 33972514) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		52 interacting genes: ACVR1 APP BYSL CCDC13 CSNK2A1 CWF19L2 DAB2 DDX6 DNAJC5 ELOA EPS15 EPS15L1 EXOSC5 FBXL7 GDF15 GRB7 GUCD1 ITSN1 KAT5 KPRP KRTAP10-1 KRTAP10-5 KRTAP13-2 KRTAP13-4 KRTAP15-1 KRTAP4-12 KRTAP6-1 KRTAP6-3 LGALS14 MAB21L3 NCK1 PCGF1 PHETA1 PHLDA2 PICALM PLAC8 PLSCR4 PRPF3 PRPH PTK6 SH2D4A SMURF1 SRPK2 SYTL4 TCEA2 TCEANC TGFB1 TRIM42 TSPAN4 ZBTB16 ZBTB24 ZNF688	20 interacting genes: ALOX5AP BORCS8-MEF2B BRME1 CBX3 COPE EHF FCHO1 HOMER3 HOXA1 IL27RA KRTAP12-2 MAPK14 MAST3 MDFI MED26 NLGN3 PDE4C SIN3B SULT2A1 TACC3
Entrez ID		23149	9518
HPRD ID		16887	05608
Ensembl ID		ENSG00000130475	ENSG00000130513
Uniprot IDs		A0A0C3SFZ9 B7ZAZ3 O14526	Q99988
PDB IDs			5VT2 5VZ3 5VZ4 6Q2J
Enriched GO Terms of Interacting Partners?
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