GDF15 and SIN3B

		GDF15	SIN3B
Description		growth differentiation factor 15	SIN3 transcription regulator family member B
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Apparatus Collagen-containing Extracellular Matrix Extracellular Exosome	Histone Deacetylase Complex Chromatin X Chromosome Y Chromosome XY Body Nucleus Nucleoplasm Cytoplasm Sin3 Complex Autosome
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity BMP Receptor Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding
	Biological Process	Reduction Of Food Intake In Response To Dietary Excess Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Myoblast Fusion	Negative Regulation Of Transcription By RNA Polymerase II Histone Deacetylation
Pathways			NoRC negatively regulates rRNA expression RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Coffee consumption ( 31046077) Growth differentiation factor-15 levels ( 29628937) Hyperemesis gravidarum ( 29563502) Liver enzyme levels (alkaline phosphatase) ( 33972514) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		20 interacting genes: ALOX5AP BORCS8-MEF2B BRME1 CBX3 COPE EHF FCHO1 HOMER3 HOXA1 IL27RA KRTAP12-2 MAPK14 MAST3 MDFI MED26 NLGN3 PDE4C SIN3B SULT2A1 TACC3	22 interacting genes: AURKA COPS2 GDF15 H3-4 HDAC1 HDAC9 IKZF1 IKZF4 MAD1L1 MXD1 MXI1 NR1D2 POR REST RNF220 SETDB1 SMARCA2 SMARCA4 SMARCB1 SMARCE1 TP53 ZBTB16
Entrez ID		9518	23309
HPRD ID		05608	09691
Ensembl ID		ENSG00000130513	ENSG00000127511
Uniprot IDs		Q99988	B7Z392 M0QYC5 O75182
PDB IDs		5VT2 5VZ3 5VZ4 6Q2J
Enriched GO Terms of Interacting Partners?
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