GDF15 and EHF

		GDF15	EHF
Description		growth differentiation factor 15	ETS homologous factor
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Apparatus Collagen-containing Extracellular Matrix Extracellular Exosome	Chromatin Nucleus Nucleoplasm Golgi Apparatus
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity BMP Receptor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity
	Biological Process	Reduction Of Food Intake In Response To Dietary Excess Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Myoblast Fusion	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Multicellular Organism Development Cell Differentiation Epithelial Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Epithelial Cell Proliferation
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Coffee consumption ( 31046077) Growth differentiation factor-15 levels ( 29628937) Hyperemesis gravidarum ( 29563502) Liver enzyme levels (alkaline phosphatase) ( 33972514) Severity of nausea and vomiting of pregnancy ( 29563502)	Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Cystic fibrosis severity ( 21602797) Gamma glutamyl transferase levels ( 29403010 33339817) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung disease severity in cystic fibrosis ( 26417704) Obesity-related traits ( 23251661) Prostate-specific antigen levels ( 28139693) Response to antipsychotic treatment ( 21107309) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder ( 34099189) Systemic lupus erythematosus ( 24871463) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Volumetric brain MRI ( 17903297)
Interacting Genes		20 interacting genes: ALOX5AP BORCS8-MEF2B BRME1 CBX3 COPE EHF FCHO1 HOMER3 HOXA1 IL27RA KRTAP12-2 MAPK14 MAST3 MDFI MED26 NLGN3 PDE4C SIN3B SULT2A1 TACC3	4 interacting genes: APP FRZB GDF15 TRAF6
Entrez ID		9518	26298
HPRD ID		05608	16105
Ensembl ID		ENSG00000130513	ENSG00000135373
Uniprot IDs		Q99988	Q9NZC4
PDB IDs		5VT2 5VZ3 5VZ4 6Q2J
Enriched GO Terms of Interacting Partners?
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