SHANK2 and PRSS1

		SHANK2	PRSS1
Description		SH3 and multiple ankyrin repeat domains 2	serine protease 1
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cellular_component Cytosol Neurofilament Plasma Membrane Postsynaptic Density Apical Plasma Membrane Growth Cone Brush Border Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Ciliary Membrane	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix Blood Microparticle
	Molecular Function	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding	Serine-type Endopeptidase Activity Metal Ion Binding
	Biological Process	Synapse Assembly Learning Positive Regulation Of Cell Population Proliferation Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Long-term Synaptic Potentiation Long-term Synaptic Depression Vocalization Behavior	Proteolysis Digestion Extracellular Matrix Disassembly
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Activation of Matrix Metalloproteinases Cobalamin (Cbl, vitamin B12) transport and metabolism
Drugs			2H-Benzimidazol-2-amine Bis(5-Amidino-Benzimidazolyl)Methane 2-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamide Nalpha-(2-Naphthylsulfonylglycyl)-3-Amidino-D,L-Phenylalanine-Isopropylester CRA_17693 N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)Isopipecolinic Acid Methyl Ester Hemi-Babim CRA_10991 Monoisopropylphosphorylserine [4-(6-Chloro-Naphthalene-2-Sulfonyl)-Piperazin-1-Yl]-(3,4,5,6-Tetrahydro-2h-[1,4']Bipyridinyl-4-Yl)-Methanone Bis(5-Amidino-2-Benzimidazolyl)Methanone 2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine 5-Amidino-Benzimidazole Amylamine CRA_16847 Bis-Benzamidine CRA_17312 Zk-806450 [4-({[5-Benzyloxy-1-(3-Carbamimidoyl-Benzyl)-1h-Indole-2-Carbonyl]-Amino}-Methyl)-Phenyl]-Trimethyl-Ammonium 2-(2-hydroxy-phenyl)-3H-benzoimidazole-5-carboxamidine CRA-9334 4-{[1-Methyl-5-(2-Methyl-Benzoimidazol-1-Ylmethyl)-1h-Benzoimidazol-2-Ylmethyl]-Amino}-Benzamidine CRA_10762 Aminomethylcyclohexane 2-(2-Hydroxy-Phenyl)-1h-Indole-5-Carboxamidine Benzylamine CRA_10655 (1R,2S)-2-Phenylcyclopropanaminium RPR131247 RWJ-56423 CRA_1802 CRA_10972 CRA_1801 [N-[N-(4-Methoxy-2,3,6-trimethylphenylsulfonyl)-L-aspartyl]-D-(4-amidino-phenylalanyl)]-piperidine Benzamidine 4-Iodobenzo[B]Thiophene-2-Carboxamidine CRA_8696 CRA_10433 Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone 4-Fluorobenzylamine RWJ-51084 1-(2-Amidinophenyl)-3-(Phenoxyphenyl)Urea ZK-806711 3,5-Diiodotyrosine (2S,3R)-2-[[4-(Tert-butylcarbamoyl)piperazine-1-carbonyl]amino]-6-(diaminomethylideneamino)-3-formylhexanoic acid bis(5-amidino-benzimidazolyl)methanone zinc CRA_11092 CRA_9785 Diminazene CRA_1144 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine Thieno[2,3-B]Pyridine-2-Carboxamidine Phosphorylisopropane Zinc;[amino-[2-[[5-[amino(azaniumylidene)methyl]benzimidazol-1-id-2-yl]methyl]benzimidazol-1-id-5-yl]methylidene]azanium [(1-{2[(4-Carbamimidoyl-Phenylamino)-Methyl]-1-Methyl-1h-Benzoimidazol-5-Yl}-Cyclopropyl)-Pyridin-2-Yl-Methyleneaminooxy]-Acetic Acid Ethyl Ester N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)-4-Acetyl-Piperazine CRA_9076 N-Alpha-(2-Naphthylsulfonyl)-N-(3-Amidino-L-Phenylalaninyl)-D-Pipecolinic Acid CRA_23653 Cyclotheonamide A Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone Hydrate 4-Phenylbutylamine Phenethylamine 1-(4-Amidinophenyl)-3-(4-Chlorophenyl)Urea Aeruginosin 98-B 3-Phenylpropylamine RPR128515 ZK-805623 Imino[2-(2-oxo-1,2-dihydro-3-pyridinyl)-1H-benzimidazol-5-yl]methanaminium Benzo[B]Thiophene-2-Carboxamidine CRA_10656 CRA_9678 4-PIPERIDIN-4-YLBUTANAL 2,5-bis-O-{3-[amino(imino)methyl]phenyl}-1,4:3,6-dianhydro-D-glucitol 2-O-(4'-AMIDINOPHENYL)-5-O-(3''-AMIDINOPHENYL)-1,4:3,6-DIANHYDRO-D-SORBITOL 2,5-O,O-BIS-{4',4''-AMIDINOPHENYL}-1,4:3,6-DIANHYDRO-D-SORBITOL 1,4:3,6-Dianhydro-2-O-(3-carbamimidoylphenyl)-5-O-(4-carbamimidoylphenyl)-D-glucitol Aprotinin diethyl [(1R)-1,5-diaminopentyl]boronate (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentylamino)ethanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexylamino)ethanoyl)pyrrolidine-2-carboxamide N-cycloheptylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide 6-fluoro-2-(2-hydroxy-3-isobutoxy-phenyl)-1H-benzoimidazole-5-carboxamidine N-cyclooctylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide 2-(2-METHYLPHENYL)-1H-INDOLE-6-CARBOXIMIDAMIDE 2-(3-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDE (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentyloxy)ethanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexyloxy)ethanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)pyrrolidine-2-carboxamide 3-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-5-METHOXY-1,1'-BIPHENYL-2-OLATE 4-(METHYLSULFONYL)BENZENECARBOXIMIDAMIDE 5-amino-2,4,6-tribromobenzene-1,3-dicarboxylic acid +/-METHYL 4-(AMINOIMINOMETHYL)-BETA-[3- INH (AMINOIMINO)PHENYL]BENZENE PENTANOATE 2-(2-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDE 2-Naphthalenesulfonic acid 1-{[1-(2-AMINO-3-PHENYL-PROPIONYL)-PYRROLIDINE-2-CARBONYL]-AMINO}-2-(3-CYANO-PHENYL)-ETHANEBORONIC ACID [N-(BENZYLOXYCARBONYL)AMINO](4-AMIDINOPHENYL)METHANE-PHOSPHONATE Nafamostat Camostat
Diseases
GWAS		Bipolar disorder ( 31043756) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Hodgkin's lymphoma ( 34216518) Kawasaki disease ( 33692975) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)	Alcoholic chronic pancreatitis ( 28754779) Cancer ( 29299148) Meconium ileus in cystic fibrosis ( 30807572) Methadone dose in opioid dependence ( 28115739) Pancreatitis ( 23143602)
Interacting Genes		33 interacting genes: ACE2 ADGRB2 ADGRL1 ADGRL2 ANO1 ARHGAP12 ARHGEF7 BAIAP2 BANF1 CLCF1 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNAJC19 DNM1 DNM2 GMNN HOMER1 MCF2 ORC2 PEX3 PPFIA1 PPP3CA PRSS1 RAB6A RHOT1 RIPOR3 SHARPIN SLC9A3 SSTR2	12 interacting genes: DEFA5 LINC00839 MRPS33 PTPN4 SERPINA1 SERPINB13 SERPINB8 SERPINF2 SHANK2 SPINK5 TST UBE3A
Entrez ID		22941	5644
HPRD ID		04479	02039
Ensembl ID		ENSG00000162105	ENSG00000204983
Uniprot IDs		A0A590UJ45 A6NHU9 C0SPH0 Q9UPX8	P07477
PDB IDs			1FXY 1TRN 2RA3 4WWY 4WXV
Enriched GO Terms of Interacting Partners?
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