SHANK2 and RHOT1

		SHANK2	RHOT1
Description		SH3 and multiple ankyrin repeat domains 2	ras homolog family member T1
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cellular_component Cytosol Neurofilament Plasma Membrane Postsynaptic Density Apical Plasma Membrane Growth Cone Brush Border Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Ciliary Membrane	Mitochondrion Mitochondrial Outer Membrane Membrane Integral Component Of Mitochondrial Outer Membrane
	Molecular Function	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding	Molecular_function GTPase Activity Calcium Ion Binding Protein Binding GTP Binding
	Biological Process	Synapse Assembly Learning Positive Regulation Of Cell Population Proliferation Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Long-term Synaptic Potentiation Long-term Synaptic Depression Vocalization Behavior	Mitochondrion Organization Small GTPase Mediated Signal Transduction Regulation Of Mitochondrion Organization Cellular Homeostasis Establishment Of Mitochondrion Localization By Microtubule Attachment Regulation Of Neurotransmitter Secretion Mitochondrion Transport Along Microtubule Mitochondrial Outer Membrane Permeabilization Regulation Of Organelle Transport Along Microtubule
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Ub-specific processing proteases RHOT1 GTPase cycle RHOT1 GTPase cycle
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Hodgkin's lymphoma ( 34216518) Kawasaki disease ( 33692975) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)	Cataracts ( 34127677) High chromosomal aberration frequency (chromosome type) ( 31586183) High chromosomal aberration frequency (chromosome type) in genotoxic compound exposure ( 31586183) Obesity-related traits ( 23251661)
Interacting Genes		33 interacting genes: ACE2 ADGRB2 ADGRL1 ADGRL2 ANO1 ARHGAP12 ARHGEF7 BAIAP2 BANF1 CLCF1 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNAJC19 DNM1 DNM2 GMNN HOMER1 MCF2 ORC2 PEX3 PPFIA1 PPP3CA PRSS1 RAB6A RHOT1 RIPOR3 SHARPIN SLC9A3 SSTR2	1 interacting genes: SHANK2
Entrez ID		22941	55288
HPRD ID		04479	15247
Ensembl ID		ENSG00000162105	ENSG00000126858
Uniprot IDs		A0A590UJ45 A6NHU9 C0SPH0 Q9UPX8	H7BXZ6 Q8IXI2
PDB IDs			5KSO 5KSP 5KSY 5KSZ 5KTY 5KU1 6D71
Enriched GO Terms of Interacting Partners?
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