SHANK2 and MCF2

		SHANK2	MCF2
Description		SH3 and multiple ankyrin repeat domains 2	MCF.2 cell line derived transforming sequence
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cellular_component Cytosol Neurofilament Plasma Membrane Postsynaptic Density Apical Plasma Membrane Growth Cone Brush Border Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Ciliary Membrane	Cytosol Cytoskeleton Membrane
	Molecular Function	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Synapse Assembly Learning Positive Regulation Of Cell Population Proliferation Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Long-term Synaptic Potentiation Long-term Synaptic Depression Vocalization Behavior	Dendrite Development Intracellular Signal Transduction Negative Regulation Of Axonogenesis Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Cellular Response To Leukemia Inhibitory Factor
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Axonal growth inhibition (RHOA activation) NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Hodgkin's lymphoma ( 34216518) Kawasaki disease ( 33692975) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)	Metabolite levels ( 23823483)
Interacting Genes		33 interacting genes: ACE2 ADGRB2 ADGRL1 ADGRL2 ANO1 ARHGAP12 ARHGEF7 BAIAP2 BANF1 CLCF1 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNAJC19 DNM1 DNM2 GMNN HOMER1 MCF2 ORC2 PEX3 PPFIA1 PPP3CA PRSS1 RAB6A RHOT1 RIPOR3 SHARPIN SLC9A3 SSTR2	9 interacting genes: ERCC3 GNA13 GNB1 RAC1 RHOA RHOG SHANK2 STUB1 TNK2
Entrez ID		22941	4168
HPRD ID		04479	02406
Ensembl ID		ENSG00000162105	ENSG00000101977
Uniprot IDs		A0A590UJ45 A6NHU9 C0SPH0 Q9UPX8	B2R9S6 P10911
PDB IDs
Enriched GO Terms of Interacting Partners?
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